Avatrombopag in adults with immune thrombocytopenia: A multicentre real-life observational study in Madrid, Spain (AVAMAD study)

被引：0

作者：

Pascual-Izquierdo, Cristina ^{[1
]}

Llacer-Ferrandis, Ma. Jose ^{[1
]}

de-la-Iglesia, Almudena ^{[2
]}

Monsalvo-Saornil, Silvia ^{[2
]}

Menor-Gomez, Maria ^{[3
]}

Gil-Fernandez, Juan Jose ^{[3
]}

Chica-Gullon, Esther ^{[4
]}

alvarez-Roman, Maria Teresa ^{[5
]}

Perez-Segura, Gloria ^{[6
]}

Zafra, Denis ^{[6
]}

Ortuzar-Pasalodos, Ariana ^{[7
]}

Gonzalez-Gascon-y-Marin, Isabel Teresa ^{[8
]}

Moreno, Gemma ^{[9
]}

Arquero-Portero, Teresa ^{[10
]}

Moreno-Carbonell, Marta ^{[1
]}

Revilla, Nuria ^{[10
]}

机构：

[1] Hosp Gen Univ Gregorio Maranon, Inst Invest Gregorio Maranon, Hematol, Madrid, Spain

[2] Hosp Univ Puerta Hierro, Hematol, Madrid, Spain

[3] Hosp Univ Principe Asturias, Hematol, Madrid, Spain

[4] Hosp Univ Getafe, Madrid, Spain

[5] Hosp Univ La Paz, Hematol, Madrid, Spain

[6] Hosp Univ 12 Octubre, Hematol, Madrid, Spain

[7] Hosp Univ Rey Juan Carlos, Hematol, Madrid, Spain

[8] Hosp Univ Infanta Leonor, Hematol, Madrid, Spain

[9] Hosp Univ Ramon & Cajal, Hematol, Madrid, Spain

[10] Hosp Univ Fdn Jimenez Diaz, Inst Invest Fdn Jimenez Diaz IIS FJD, Hematol, Madrid, Spain

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2025年 / 206卷 / 02期

关键词：

avatrombopag; immune thrombocytopenia; ITP; TPO-RA;

D O I：

10.1111/bjh.19975

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immune thrombocytopenia (ITP) is a rare acquired disorder where thrombopoietin-receptor agonists have become mainstays of ITP treatment. With the recent approval of avatrombopag (AVA), real-world studies are essential to evaluate its efficacy and safety. Our study of 66 adult ITP patients treated with AVA showed a high response rate. After starting AVA, 74.2% did not require rescue medications, with minimal adverse effects. Additionally, 56.0% of patients reduced other ITP medications, and all patients aged >= 65 years responded to AVA. Results should be confirmed in larger studies, but AVA appears to be an effective and safe treatment for ITP patients.

引用

页码：652 / 656

页数：5

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