NECTIN4 modulates tumor microenvironment and shapes the response to immune checkpoint blockade in bladder cancer

被引：0
|
作者：
Maenosono, Ryoichi [1 ,2 ]
Nishimura, Kazuki [1 ,2 ]
Hirosuna, Kensuke [3 ]
Komura, Kazumasa [2 ]
Owari, Takuya [4 ]
Kawachi, Asuka [1 ]
Mukohyama, Junko [1 ,5 ]
Ishida, Mitsuaki [6 ]
Zenkoh, Junko [7 ]
Ajiro, Masahiko [1 ]
Suzuki, Yutaka [7 ]
Nishikawa, Hiroyoshi [4 ]
Koyama, Shohei [4 ]
Azuma, Haruhito [2 ]
Yoshimi, Akihide [1 ]
机构：
[1] Natl Canc Ctr, Res Inst, Div Canc RNA Res, Tokyo, Japan
[2] Osaka Med & Pharmaceut Univ, Dept Urol, Takatsuki, Osaka, Japan
[3] Okayama Univ, Grad Sch Med, Dept Regenerat Sci, Okayama, Japan
[4] Natl Canc Ctr, EPOC, Div Canc Immunol, Tokyo, Japan
[5] Univ Tokyo, Inst Med Sci, Dept Surg, Tokyo, Japan
[6] Osaka Med & Pharmaceut Univ, Dept Pathol, Takatsuki, Osaka, Japan
[7] Univ Tokyo, Dept Computat Biol & Med Sci, Tokyo, Japan
来源：
CANCER SCIENCE | 2025年 / 116卷
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
P-3246
引用
收藏
页码：1706 / 1706
页数：1
相关论文
共 50 条
  • [1] The Tumor Microenvironment in the Response to Immune Checkpoint Blockade Therapies
    Petitprez, Florent
    Meylan, Maxime
    de Reynies, Aurelien
    Sautes-Fridman, Catherine
    Fridman, Wolf H.
    FRONTIERS IN IMMUNOLOGY, 2020, 11
  • [2] Repurposing macitentan with nanoparticle modulates tumor microenvironment to potentiate immune checkpoint blockade
    Son, Soyoung
    Shin, Jung Min
    Shin, Sol
    Kim, Chan Ho
    Lee, Jae Ah
    Ko, Hyewon
    Lee, Eun Sook
    Jung, Jae Min
    Kim, Jeongyun
    Park, Jae Hyung
    BIOMATERIALS, 2021, 276 (276)
  • [3] The interaction of CD4+ helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response
    Merav Cohen
    Amir Giladi
    Oren Barboy
    Pauline Hamon
    Baoguo Li
    Mor Zada
    Anna Gurevich-Shapiro
    Cristian Gabriel Beccaria
    Eyal David
    Barbara B. Maier
    Mark Buckup
    Iris Kamer
    Aleksandra Deczkowska
    Jessica Le Berichel
    Jair Bar
    Matteo Iannacone
    Amos Tanay
    Miriam Merad
    Ido Amit
    Nature Cancer, 2022, 3 : 303 - 317
  • [4] The interaction of CD4+ helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response
    Cohen, Merav
    Giladi, Amir
    Barboy, Oren
    Hamon, Pauline
    Li, Baoguo
    Zada, Mor
    Gurevich-Shapiro, Anna
    Beccaria, Cristian Gabriel
    David, Eyal
    Maier, Barbara B.
    Buckup, Mark
    Kamer, Iris
    Deczkowska, Aleksandra
    Le Berichel, Jessica
    Bar, Jair
    Iannacone, Matteo
    Tanay, Amos
    Merad, Miriam
    Amit, Ido
    NATURE CANCER, 2022, 3 (03) : 303 - +
  • [5] Statin shapes inflamed tumor microenvironment and enhances immune checkpoint blockade in non-small cell cancer
    Mao, Wenjun
    Cai, Yun
    Chen, Danrong
    Jiang, Guanyu
    Xu, Yongrui
    Chen, Ruo
    Wang, Fengxu
    Wang, Xuehai
    Zheng, Mingfeng
    Zhao, Xinyuan
    Mei, Jie
    JCI INSIGHT, 2022, 7 (18)
  • [6] Small-molecule PIK-93 modulates the tumor microenvironment to improve immune checkpoint blockade response
    Lin, Chia-Yi
    Huang, Kuo-Yen
    Kao, Shih-Han
    Lin, Ming-Shiu
    Lin, Chih-Chien
    Yang, Shuenn-Chen
    Chung, Wei-Chia
    Chang, Ya-Hsuan
    Chein, Rong-Jie
    Yang, Pan-Chyr
    SCIENCE ADVANCES, 2023, 9 (14)
  • [7] Pharmacologic Inhibition of FGFR Modulates the Metastatic Immune Microenvironment and Promotes Response to Immune Checkpoint Blockade
    Akhand, Saeed S.
    Liu, Zian
    Purdy, Stephen C.
    Abdullah, Ammara
    Lin, Hang
    Cresswell, Gregory M.
    Ratliff, Timothy L.
    Wendt, Michael
    CANCER IMMUNOLOGY RESEARCH, 2020, 8 (12) : 1542 - 1553
  • [8] Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer
    Zhou, Qian
    Liang, Jinxia
    Yang, Tong
    Liu, Jin
    Li, Bo
    Li, Yingchang
    Fan, Zhenzhen
    Wang, Weida
    Chen, Wensheng
    Yuan, Sujing
    Xu, Meng
    Xu, Qigui
    Luan, Zhidong
    Xia, Zhongjun
    Zhou, Penghui
    Huang, Yadong
    Chen, Liang
    EMBO MOLECULAR MEDICINE, 2022, 14 (01)
  • [9] Nectin4 is a novel TIGIT ligand which combines checkpoint inhibition and tumor specificity
    Reches, Adi
    Ophir, Yael
    Stein, Natan
    Kol, Inbal
    Isaacson, Batya
    Charpak Amikam, Yoav
    Elnekave, Afek
    Tsukerman, Pinchas
    Kucan Brlic, Paola
    Lenac, Tihana
    Seliger, Barbara
    Jonjic, Stipan
    Mandelboim, Ofer
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 (01)
  • [10] Role of the cancer cell proteome and tumor microenvironment in the hyperprogression (HP) phenotype response to immune checkpoint blockade
    George, Andrew
    Sahin, Ilyas
    Zhang, Shengliang
    El-Deiry, Wafik S.
    CANCER RESEARCH, 2022, 82 (12)
12345