Homobarrelenones: Versatile Building Blocks for the Construction of Novel and Structurally Diverse Scaffolds

被引：0

作者：

Lucero, Valeria ^{[1
]}

do Carmo, Hugo ^{[1
]}

Fernandez, Gabriel ^{[1
]}

Cabrera, Mauricio ^{[2
]}

Eugui, Macarena ^{[1
]}

Moyna, Guillermo ^{[1
]}

机构：

[1] Univ Republ, Dept Quim Litoral, CENUR Litoral Norte, Ruta 3 km 363, Paysandu, Uruguay

[2] Univ Republ, Dept Ciencias Biol, CENUR Litoral Norte, Ruta 3 km 363, Paysandu, Uruguay

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2024年

关键词：

Base-catalyzed solvolysis; Catalytic hydrogenation; Homobarrelenones; Hydride reduction; Sperm motility; BOAR SPERMATOZOA; CYCLOADDITION; CASCADE; TROPONE; AGENTS;

D O I：

10.1002/ejoc.202400887

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe the derivatization of tropolone-based homobarrelenones through simple transformations, including catalytic hydrogenations, base-catalyzed solvolysis, and hydride reductions. Despite being structurally complex and highly functionalized, the novel compounds had no significant cytotoxicity in sperm motility assays, underscoring the importance of Michael acceptor moieties in the biological activity of this class of compounds.

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页数：5

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