Unusual Synchronous Multiple Primary Early-Stage Lung Adenocarcinoma with Concomitant MET Exon 14 Skipping, PIK3CA and KRAS Mutations: A Case Report

被引：0

作者：

Zhang, Yongjing ^{[1
]}

Gao, Qiqi ^{[1
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 1, Dept Pathol, Sch Med, Hangzhou, Peoples R China

来源：

CASE REPORTS IN ONCOLOGY | 2024年 / 17卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Synchronous multiple primary lung cancer; Concurrent mutations; Multiple gene mutations; Case report; GROUND-GLASS; CANCER; FEATURES; DISCREPANCY;

D O I：

10.1159/000540355

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Instruction: Synchronous multiple primary lung cancer (sMPLC) constitutes a distinct subtype of NSCLC, where accurate diagnosis and prognostic evaluation remain challenging. Case Presentation: The case involves a 70-year-old male patient admitted to the hospital due to bilateral pulmonary nodules. The patient underwent staged resection. Molecular pathological examination revealed that tumor A harbored concurrent mutations in MET exon 14 skipping and PIK3CA (p.E545K), while tumor B exhibited a KRAS exon 2 (p.G12S/D) mutation. Postoperatively, the patient demonstrated a favorable recovery, with no evidence of recurrence for 1 year. Conclusion: This study presents a case of sMPLC in early-stage lung cancer, illustrating the genetic heterogeneity in early-stage lung adenocarcinoma and underscoring the significance of precise evaluation of sMPLC and intrapulmonary metastases.

引用

页码：874 / 881

页数：8