BP1223, a Novel T Cell Engager Targeting CD39 for Potent Antitumor Activity in Acute Myeloid Leukemia

被引：0
|
作者：
Yuda, Junichiro [1 ]
Aramaki, Takahiko [2 ]
Matsumura, Haruka [2 ]
Nakajima, Kanto [2 ]
Mie, Motoya [2 ]
机构：
[1] Natl Canc Ctr Hosp East, Dept Expt Therapeut, Kashiwa, Japan
[2] BrightPath Biotherapeut Co Ltd, Kawasaki Res Labs, Kawasaki, Japan
来源：
BLOOD | 2024年 / 144卷
关键词：
D O I：
10.1182/blood-2024-200048
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：4146 / 4147
页数：2
相关论文
共 50 条
  • [1] CD123-Engager T Cells as a Novel Immunotherapeutic for Acute Myeloid Leukemia
    Bonifant, Challice L.
    Szoor, Arpad
    Torres, David
    Joseph, Nicholos
    Velasquez, Mireya Paulina
    Iwahori, Kota
    Gaikwad, Amos
    Phuong Nguyen
    Arber, Caroline
    Song, Xiao-Tong
    Redell, Michele
    Gottschalk, Stephen
    MOLECULAR THERAPY, 2016, 24 (09) : 1615 - 1626
  • [2] Immunotherapy of Acute Myeloid Leukemia Enabled By Targeting of Pan-Cancer Molecular Patterns with a Novel Trispecific T Cell Engager
    Varkey, Ashley
    Bariana, Manpreet
    Cassella, Elena
    Anuncio, Shaina
    Batistick, Mark
    Sequeira, Sonia
    Ahmed, Mahiuddin
    Zakrzewski, Johannes
    BLOOD, 2024, 144 : 824 - 825
  • [3] Targeting CD38 with isatuximab and a novel CD38/CD3xCD28 trispecific T-cell engager in older patients with acute myeloid leukemia
    Martin-Sanchez, Esperanza
    Blanco, Laura
    Kim, Peter S.
    Bisht, Kamlesh
    Wang, Hongfang
    van de Velde, Helgi
    Jelinek, Tomas
    Simoes, Catia
    Prosper, Felipe
    Miguel, Jesus F. San
    Alfonso, Ana
    Bergua, Juan
    Rodriguez-Veiga, Rebeca
    Vives, Susana
    Martinez-Cuadron, David
    Montesinos, Pau
    Paiva, Bruno
    Zabaleta, Aintzane
    BLOOD ADVANCES, 2024, 8 (15) : 3875 - 3879
  • [4] Control of acute myeloid leukemia by a trifunctional NKp46-CD16a-NK cell engager targeting CD123
    Gauthier, Laurent
    Virone-Oddos, Angela
    Beninga, Jochen
    Rossi, Benjamin
    Nicolazzi, Celine
    Amara, Celine
    Blanchard-Alvarez, Audrey
    Gourdin, Nicolas
    Courta, Jacqueline
    Basset, Alexandra
    Agnel, Magali
    Guillot, Franceline
    Grondin, Gwendoline
    Bonnevaux, Helene
    Bauchet, Anne-Laure
    Morel, Ariane
    Morel, Yannis
    Chiron, Marielle
    Vivier, Eric
    NATURE BIOTECHNOLOGY, 2023, 41 (09) : 1296 - +
  • [5] Control of acute myeloid leukemia by a trifunctional NKp46-CD16a-NK cell engager targeting CD123
    Laurent Gauthier
    Angela Virone-Oddos
    Jochen Beninga
    Benjamin Rossi
    Céline Nicolazzi
    Céline Amara
    Audrey Blanchard-Alvarez
    Nicolas Gourdin
    Jacqueline Courta
    Alexandra Basset
    Magali Agnel
    Franceline Guillot
    Gwendoline Grondin
    Hélène Bonnevaux
    Anne-Laure Bauchet
    Ariane Morel
    Yannis Morel
    Marielle Chiron
    Eric Vivier
    Nature Biotechnology, 2023, 41 : 1296 - 1306
  • [6] Antitumor activity of the potent and novel FLT3 inhibitor HM43239 in acute myeloid leukemia
    Lee, Miyoung
    Ha, Young Eun
    Moon, Mi Jin
    Byun, Joo-Yun
    Yu, HyunKyung
    Kang, SeokJong
    Lee, Jaeho
    Lee, Kyuhang
    Kim, Eunkyung
    Kim, Eunyoung
    Lee, Ho Jeong
    Kim, YoungHoon
    Ahn, YoungGil
    Suh, KweeHyun
    Kim, Sun-Jin
    CANCER RESEARCH, 2018, 78 (13)
  • [7] Potent antitumor activity of a bispecific T-cell engager antibody targeting the intracellular antigen KRAS G12V
    Lu, Changchang
    Zou, Lu
    Wang, Qiaoli
    Sun, Mengna
    Shi, Tianyu
    Xu, Shuang
    Meng, Fanyan
    Du, Juan
    BIOMOLECULES AND BIOMEDICINE, 2024, 24 (05): : 1424 - 1434
  • [8] A Novel CD34-Specific T-Cell Engager Efficiently Depletes Stem Cells and Acute Myeloid Leukemia Cells in Vitro and In Vivo
    Arruda, Lucas C. M.
    Jin, Liqing
    Lambert, Melanie
    Rivera, Laura Sanchez
    Alvez, Renato
    de Moura, Tales Rocha
    Mim, Carsten
    Axelsson-Robertson, Rebecca
    Dick, John E.
    Mattsson, Jonas
    Onfelt, Bjorn
    Carlsten, Mattias
    Uhlin, Michael
    BLOOD, 2021, 138
  • [9] A novel CD34-specific T-cell engager efficiently depletes acute myeloid leukemia and leukemic stem cells in vitro and in vivo
    Arruda, Lucas C. M.
    Stikvoort, Arwen
    Lambert, Melanie
    Jin, Liqing
    Rivera, Laura Sanchez
    Alves, Renato M. P.
    de Moura, Tales Rocha
    Mim, Carsten
    Lehmann, Soren
    Axelsson-Robertson, Rebecca
    Dick, John E.
    Mattsson, Jonas
    Onfelt, Bjorn
    Carlsten, Mattias
    Uhlin, Michael
    HAEMATOLOGICA, 2022, 107 (08) : 1786 - 1795
  • [10] Antitumor activity of a potent MNK inhibitor NSP-1047 in acute myeloid leukemia
    Li, Bing
    Huang, Qionglin
    Zhang, Ke
    Zhang, Jianming
    CANCER RESEARCH, 2023, 83 (07)
12345