A Case of Tiopronin-induced Membranous Nephropathy Presenting with IgG4-predominant Staining Pattern

被引：0
|
作者：
Yamashita, Jumpei [1 ]
Hirakawa, Yosuke [1 ]
Sato, Yusuke [2 ,3 ]
Abe, Hiroyuki [4 ]
Akiyama, Shin'ichi [5 ]
Maruyama, Shoichi [5 ]
Kume, Haruki [2 ]
Nangaku, Masaomi
机构：
[1] Univ Tokyo, Sch Med, Div Nephrol & Endocrinol, Tokyo, Japan
[2] Univ Tokyo, Grad Sch Med, Dept Urol, Tokyo, Japan
[3] Tokyo Metropolitan Tama Med Ctr, Dept Urol, Tokyo, Japan
[4] Univ Tokyo, Grad Sch Med, Dept Pathol, Tokyo, Japan
[5] Nagoya Univ, Grad Sch Med, Dept Nephrol, Nagoya, Japan
来源：
INTERNAL MEDICINE | 2024年
关键词：
Tiopronin; Membranous nephropathy; Nephrotic syndrome;
D O I：
10.2169/internalmedicine.4047-24
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Tiopronin is a key drug used to treat cystinuria. A 41-year-old Japanese woman with cystinuria presented with eyelid edema and weight gain after the administration of tiopronin. Her serum albumin was 1.8 g/dL and her urinary protein level was 5.5 g/gCre. After cessation of tiopronin, she achieved remission of nephrotic syndrome (NS). Secondary NS due to tiopronin was evident based on the clinical course and laboratory values. A kidney biopsy showed membranous nephropathy (MN), and an immunofluorescence analysis revealed strong deposition of immunoglobulin G4 (IgG4). However, a previous case report of tiopronin-induced MN showed staining for IgG1 and IgG3. This case report suggests a novel etiology for tiopronin-induced MN.
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页数：5
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