CCK2 receptors in chronic pain

被引：6
|
作者：
LaVigne, Justin E. [1 ]
Alles, Sascha R. A. [1 ]
机构：
[1] Univ New Mexico, Sch Med, Dept Anesthesiol & Crit Care Med, Albuquerque, NM 87109 USA
来源：
NEUROBIOLOGY OF PAIN | 2022年 / 11卷
关键词：
CCK2; Cholecystokinin; Chronic pain; Non-opioid treatment; PREVENTS MORPHINE-TOLERANCE; ANTAGONIST L-365,260; CHOLECYSTOKININ-OCTAPEPTIDE; B RECEPTOR; SPINAL CHOLECYSTOKININ; SELECTIVE ANTAGONIST; INDUCED HYPERALGESIA; INDUCED ANALGESIA; OPIOID ANALGESIA; NEUROPATHIC PAIN;
D O I：
10.1016/j.ynpai.2022.100092
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The cholecystokinin receptor system, specifically cholecystokinin 2 receptor (CCK2R) is a historic target for pain management that has shown limited success. However, new approaches to target CCK2R have incited fresh enthusiasm for this target. In this mini-review, we discuss what is known about CCK2R in peripheral and central circuits under na & iuml;ve physiological conditions and under conditions of chronic pain, the interactions of CCK2Rs with opioids and briefly, recent efforts to develop new treatments targeting CCK2R for chronic pain.
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页数：5
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