Dental biofilm acidogenicity induced by pediatric oral medications: a double-blind randomized clinical trial

被引:0
|
作者
de Alencar, Karla Pinheiro [1 ]
Peixoto, Daniel Fernandes [1 ]
Maximo, Fabio do Nascimento [1 ]
Farias, Isabela Albuquerque Passos [2 ]
Sampaio, Fabio Correia [3 ]
机构
[1] Univ Fed Paraiba UFPB, Lab Oral Biol, Joao Pessoa, PB, Brazil
[2] Univ Fed Paraiba UFPB, Dept Restorat Dent, Joao Pessoa, PB, Brazil
[3] Univ Fed Paraiba UFPB, Dept Clin & Social Dent, Joao Pessoa, PB, Brazil
来源
BRAZILIAN ORAL RESEARCH | 2024年 / 38卷
关键词
Dental Plaque; Administration; Oral; Dental Caries; CHILDREN; PH;
D O I
10.1590/1807-3107bor-2024.vol38.0107
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
The aim of this study was to evaluate in vivo dental biofilm acidogenicity induced by nine long-term pediatric oral liquid medications (OLMs). A double-blind crossover randomized clinical trial was conducted with 12 individuals aged 18 to 22 years who had good oral hygiene (OSI < 1.1) and a DMFT index of less than 12. Each participant was exposed to nine OLMs and a 10% sucrose solution (positive control) as part of the crossover design. The pH of the dental biofilm was measured with a Beetrode (R) microelectrode at 0, 5, 10, 15, 20, 25, and 30 min. Statistical analysis was performed to determine the minimum pH and the area under the curve (AUC). One-way ANOVA was utilized, and the significance level was set at 0.05. Pediatric OLMs caused a sucrose-like decrease in biofilm pH, regardless of therapeutic class (p > 0.05). The mean +/- standard deviation of the AUC ranged from 16.26 +/- 11.59 (cetirizine) to 39.22 +/- 20.81 (azithromycin), with no statistically significant difference compared to sucrose (25.22 +/- 6.97) (p > 0.05). The findings suggest that pediatric OLMs contribute to dental biofilm acidogenicity, with a more pronounced effect induced by medications used for respiratory diseases and also by antibiotics.
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页数:6
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