Gliadin-dependent UPR induction directly triggers the expression of TG2 and pro-inflammatory cytokines, dysregulates intestinal permeability, and reduces CFTR expression in intestinal epithelial cells of celiac disease patients

被引：0

作者：

Romina Monzani ^{[1
]}

Mara Gagliardi ^{[1
]}

Valentina Saverio ^{[2
]}

Nausicaa Clemente ^{[1
]}

Alice Monzani ^{[2
]}

Ivana Rabbone ^{[3
]}

Francesca Nigrelli ^{[4
]}

Samuele Pellizzaro ^{[4
]}

Emanuele Ferrario ^{[1
]}

Silvia Saettone ^{[5
]}

Nico Pagano ^{[1
]}

Luigina De Leo ^{[6
]}

Dmitry Lim ^{[6
]}

Daniele Sblattero ^{[7
]}

Marco Corazzari ^{[8
]}

机构：

[1] University of Piemonte Orientale,Department of Health Sciences, School of Medicine, Center for Translational Research on Autoimmune and Allergic Disease (CAAD)

[2] University of Piemonte Orientale,Interdisciplinary Research Center of Autoimmune Diseases (IRCAD)

[3] University of Piemonte Orientale,Department of Health Sciences

[4] University of Piemonte Orientale,Division of Pediatrics, Department of Health Sciences

[5] University of Trieste,Department of Life Sciences

[6] University Hospital Maggiore della Carità,Gastroenterology Unit, Department of Oncological and Specialty Medicine

[7] I.R.C.C.S. Burlo Garofolo,Institute for Maternal and Child Health

[8] University of Piemonte Orientale,Department of Pharmaceutical Sciences

来源：

Biology Direct | / 20卷 / 1期

关键词：

CD; Chemical chaperone; UPR; Endoplasmic reticulum stress; IEC;

D O I：

10.1186/s13062-025-00644-9

中图分类号：

学科分类号：

摘要：

引用

共 6 条

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PL Sappington
X Han
RL Delude
MP Fink
Critical Care, 6 (Suppl 1):
[4] Gliadin stimulation. of murine macrophage inflammatory gene expression and intestinal permeability are MyD88-dependent: Role of the innate immune response in celiac disease
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Fasano, A
Vogel, SN
JOURNAL OF IMMUNOLOGY, 2006, 176 (04): : 2512 - 2521
[5] Decreased expression of TLR-4 and MD-2 by intestinal epithelial cells (IEC) protects against dysregulated signaling and pro-inflammatory gene expression in response to bacterial lipopolysaccharide (LPS)
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Vora, P
Faure, E
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GASTROENTEROLOGY, 2001, 120 (05) : A704 - A704
[6] Differential regulation of glutathione S-transferase alpha expression by pro- and anti-inflammatory cytokines in cultured human intestinal epithelial (CACO-2) cells.
Higgins, MA
Boudreau, KA
Kirby, GM
FASEB JOURNAL, 1999, 13 (05): : A843 - A843

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