Design of the Phase 4 REMODEL study assessing the effect of dupilumab on esophageal function and remodeling in adults with active eosinophilic esophagitis

被引：0
|
作者：
Hirano, Ikuo [1 ]
Biedermann, Luc [2 ]
Cunoosamy, Danen [3 ]
Dellon, Evan S. [4 ]
Bredenoord, Albert J. [5 ]
Savarino, Edoardo V. [6 ]
Zhang, Mei [3 ]
Durrani, Sandy [7 ]
Pela, Tiffany [3 ]
Radwan, Amr [7 ]
Jacob-Nara, Juby [3 ]
机构：
[1] Northwestern Univ, Div Gastroenterol & Hepatol, Feinberg Sch Med, Chicago, IL USA
[2] Univ Spital Zurich, Klin Gastroenterol & Hepatol, Zurich, Switzerland
[3] Sanofi, Bridgewater, MA USA
[4] Univ N Carolina, Sch Med, Ctr Esophageal Dis & Swallowing, Chapel Hill, NC USA
[5] Acad Med Ctr, Dept Gastroenterol & Hepatol, Amsterdam, Netherlands
[6] Univ Hosp Padova, Dept Surg Oncol & Gastroenterol Serv, Padua, Italy
[7] Regeneron Pharmaceut Inc, Tarrytown, NV USA
来源：
SWISS MEDICAL WEEKLY | 2024年 / 154卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：35S / 35S
页数：1
相关论文
共 9 条
  • [1] Design of the Phase 4 REMODEL Study Assessing the Effect of Dupilumab on Esophageal Function and Remodeling in Adult Patients With Active Eosinophilic Esophagitis
    Hirano, Ikuo
    Cunoosamy, Danen
    Dellon, Evan S.
    Bredenoord, Arjan
    Savarino, Edoardo
    Zhang, Mei
    Raphael, Bram P.
    Pela, Tiffany
    Radwan, Amr
    Jacob-Nara, Juby A.
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2024, 119 (10S): : S449 - S449
  • [2] Efficacy of Dupilumab in a Phase 2 Randomized Trial of Adults With Active Eosinophilic Esophagitis
    Hirano, Ikuo
    Dellon, Evan S.
    Hamilton, Jennifer D.
    Collins, Margaret H.
    Peterson, Kathryn
    Chehade, Mirna
    Schoepfer, Alain M.
    Safroneeva, Ekaterina
    Rothenberg, Marc E.
    Falk, Gary W.
    Assouline-Dayan, Yehudith
    Zhao, Qiong
    Chen, Zhen
    Swanson, Brian N.
    Pirozzi, Gianluca
    Mannent, Leda
    Graham, Neil M. H.
    Akinlade, Bolanle
    Stahl, Neil
    Yancopoulos, George D.
    Radin, Allen
    GASTROENTEROLOGY, 2020, 158 (01) : 111 - +
  • [3] DUPILUMAB IMPROVES INFLAMMATORY AND REMODELING ASPECTS OF ENDOSCOPIC DISEASE ACTIVITY IN EOSINOPHILIC ESOPHAGITIS: RESULTS FROM THE PHASE 3 LIBERTY-EOE-TREET STUDY
    Hirano, Ikuo
    Collins, Margaret H.
    Dellon, Evan S.
    Sun, Xian
    Beazley, Bethany
    Glotfelty, Lila
    Shabbir, Arsalan
    Giannelou, Angeliki
    GASTROENTEROLOGY, 2023, 164 (06) : S346 - S346
  • [4] DUPILUMAB IMPROVES INFLAMMATORY AND REMODELING ASPECTS OF ENDOSCOPIC DISEASE ACTIVITY IN EOSINOPHILIC ESOPHAGITIS: RESULTS FROM THE PHASE 3 LIBERTY-EOE-TREET STUDY
    Pellegatta, G.
    Hirano, I.
    Collins, M. H.
    Dellon, E. S.
    Sun, X.
    Glotfelty, L.
    Shabbir, A.
    DIGESTIVE AND LIVER DISEASE, 2024, 56 : S172 - S173
  • [5] A Phase 2 Study Design to Investigate the Efficacy and Safety of Dupilumab Therapy Compared With Placebo in Adults With Moderately to Severely Active Ulcerative Colitis With an Eosinophilic Phenotype
    Binion, David
    Feagan, Brian G.
    Mortensen, Eric
    Laws, Elizabeth
    Maloney, Jennifer
    Martincova, Renata
    Radin, Allen
    Glotfelty, Lila
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2023, 118 (10): : S159 - S160
  • [6] CORRELATION BETWEEN ESOPHAGEAL DISTENSIBILITY AND OBJECTIVE MEASURES OF DISEASE IN PATIENTS WITH ACTIVE EOSINOPHILIC ESOPHAGITIS: A POST HOC ANALYSIS OF A RANDOMIZED, PLACEBO-CONTROLLED, PHASE 2 DUPILUMAB TRIAL
    Hirano, Ikuo
    Hamilton, Jennifer D.
    Collins, Margaret H.
    Lin, Zhiyue
    Dellon, Evan S.
    Chen, Zhen
    Peterson, Kathryn A.
    Chehade, Mirna
    Schoepfer, Alain M.
    Safroneeva, Ekaterina
    Rothenberg, Marc E.
    Falk, Gary W.
    Assouline-Dayan, Yehudith
    Pirozzi, Gianluca
    Mannent, Leda
    Graham, Neil M.
    Ruddy, Marcella
    Radin, Allen
    GASTROENTEROLOGY, 2018, 154 (06) : S244 - S244
  • [7] DUPILUMAB IMPROVES INFLAMMATORY AND REMODELING ASPECTS OF ENDOSCOPIC DISEASE ACTIVITY IN EOSINOPHILIC ESOPHAGITIS: 52-WEEK RESULTS FROM THE PHASE 3 LIBERTY EOE TREET STUDY
    Hirano, Ikuo
    Dellon, Evan S.
    Pellegatta, Gaia
    Xia, Changming
    Pela, Tiffany
    Durrani, Sandy
    Jacob-Nara, Juby A.
    Radwan, Amr
    GASTROENTEROLOGY, 2024, 166 (05) : S402 - S403
  • [8] A phase 2 study investigating the efficacy and safety of dupilumab versus placebo in adults with moderately to severely active ulcerative colitis with an eosinophilic phenotype
    Gottlieb, E.
    Binion, D.
    Feagan, B.
    Laws, E.
    Nivens, C.
    Maloney, J.
    Abdulai, R.
    Radin, A.
    Glotfelty, L.
    JOURNAL OF CROHNS & COLITIS, 2024, 18 : I1354 - I1355
  • [9] An Adaptive Phase 2/3 Study Design to Investigate the Efficacy and Safety of Dupilumab Therapy Compared With Placebo in Adults and Adolescents With Eosinophilic Gastritis With or Without Eosinophilic Duodenitis
    Dellon, Evan S.
    Rothenberg, Marc E.
    Chehade, Mirna
    Mortensen, Eric
    Laws, Elizabeth
    Maloney, Jennifer
    Martincova, Renata
    Paleczny, Heather
    Glotfelty, Lila
    Shabbir, Arsalan
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2023, 118 (10): : S1392 - S1393
1