VALPROIC ACID AND PLASMA-LEVELS OF PHENYTOIN

被引：34
|
作者：
BRUNI, J
WILDER, BJ
WILLMORE, LJ
BARBOUR, B
机构：
[1] VET ADM HOSP, MED CTR, NEUROL SERV 127, GAINESVILLE, FL 32602 USA
[2] UNIV FLORIDA, COLL MED, DEPT NEUROL, GAINESVILLE, FL 32611 USA
来源：
NEUROLOGY | 1979年 / 29卷 / 06期
关键词：
D O I：
10.1212/WNL.29.6.904
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Seizure patients (8) were treated concurrently with a constant dose of the anticonvulsants phenytoin and valproic acid for 1 yr. During initial therapy with valproic acid total plasma phenytoin levels decreased. The interaction was transient and was not seen at the end of 1 yr. Total plasma phenytoin levels returned to pre-valproic-acid levels in 7 patients.
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页码：904 / 905
页数：2
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