XPO1 inhibition as a clinically viable strategy to enhance durability of response to KRASG12D inhibitor in pancreatic ductal adenocarcinoma

被引：0
|
作者：
Al Hallak, Mohammed Najeeb
Khan, Husain Yar
Aboukameel, Amro
Bannoura, Sahar
Choucair, Khalil
Beal, Eliza W.
Tobon, Miguel
Beydoun, Rafic
Shields, Anthony F.
Mohammad, Ramzi
Beebe-Dimmer, Jennifer Lynn
Philip, Philip Agop
Pasche, Boris
Azmi, Asfar S.
机构：
[1] Wayne State Univ, Barbara Ann Karmanos Canc Inst, Detroit, MI USA
[2] Wayne State Univ, Detroit, MI USA
[3] Wayne State Univ, Henry Ford Canc Inst, Sch Med, Detroit, MI USA
[4] SWOG, Detroit, MI USA
来源：
JOURNAL OF CLINICAL ONCOLOGY | 2025年 / 43卷 / 4_SUPPL期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1200/JCO.2025.43.4_suppl.736
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：736 / 736
页数：1
相关论文
共 50 条
  • [1] KrasG12D effector dependencies in the maintenance of pancreatic ductal adenocarcinoma
    Grimont, Adrien
    Zhao, Zhen
    Leach, Steven D.
    Chandwani, Rohit
    CANCER RESEARCH, 2019, 79 (24)
  • [2] Deciphering acquired resistance to KRASG12D inhibition in a mouse model of pancreatic ductal adenocarcinoma
    Dilly, Julien
    Abbassi, Laleh
    Hennessey, Connor J.
    Uribe, Giselle A.
    Parent, Brendan
    Yang, Annan
    Kapner, Kevin S.
    Li, Ziyue
    Dasgupta, Shatavisha
    Jordan, Alexander
    Hoffman, Megan T.
    Qiang, Li
    Hambitzer, Felix P.
    Chugh, Seema
    Shalek, Alex K.
    Dougan, Stephanie K.
    Wolpin, Brian M.
    Nowak, Jonathan A.
    Raghavan, Srivatsan
    Winter, Peter S.
    Aguirre, Andrew J.
    CANCER RESEARCH, 2024, 84 (02)
  • [3] Dual Inhibition of KRASG12D and Pan-ERBB Is Synergistic in Pancreatic Ductal Adenocarcinoma
    Gulay, Kevin Christian Montecillo
    Zhang, Xinlian
    Pantazopoulou, Vasiliki
    Patel, Jay
    Esparza, Edgar
    Pran Babu, Deepa Sheik
    Ogawa, Satoshi
    Weitz, Jonathan
    Ng, Isabella
    Mose, Evangeline S.
    Pu, Minya
    Engle, Dannielle D.
    Lowy, Andrew M.
    Tiriac, Herve
    CANCER RESEARCH, 2023, 83 (18) : 3001 - 3012
  • [4] Dissecting acquired resistance to KRASG12D inhibition in a mouse model of pancreatic ductal adenocarcinoma
    Dilly, Julien
    Abbassi, Laleh
    Hennessey, Connor J.
    Uribe, Giselle A.
    Parent, Brendan
    Yang, Annan
    Kapner, Kevin S.
    Li, Ziyue
    Evans, Kyle E.
    Dasgupta, Shatavisha
    Hoffman, Megan T.
    Qiang, Li
    Hambitzer, Felix P.
    Chugh, Seema
    Shalek, Alex K.
    Dougan, Stephanie K.
    Wolpin, Brian M.
    Nowak, Jonathan A.
    Raghavan, Srivatsan
    Winter, Peter S.
    Aguirre, Andrew J.
    CANCER RESEARCH, 2024, 84 (06)
  • [5] MGST1 facilitates novel KRASG12D inhibitor resistance in KRASG12D-mutated pancreatic ductal adenocarcinoma by inhibiting ferroptosis
    Xu, Chungui
    Lin, Weihao
    Zhang, Qi
    Ma, Yarui
    Wang, Xue
    Guo, Ai
    Zhu, Guiling
    Zhou, Zhendiao
    Song, Weiwei
    Zhao, Ziyi
    Jiao, Yuchen
    Wang, Xiaobing
    Du, Chunxia
    MOLECULAR MEDICINE, 2024, 30 (01)
  • [6] KEAP1-NRF2 mediated resistance against KRASG12D inhibitor in pancreatic ductal adenocarcinoma
    Chang, Wen-Hsuan
    Stamey, Addison G.
    Waters, Andrew M.
    Bryant, Kirsten L.
    Cox, Adrienne D.
    Der, Channing J.
    CANCER RESEARCH, 2024, 84 (06)
  • [7] Reshaping the Tumor Microenvironment of KRASG12D Pancreatic Ductal Adenocarcinoma with Combined SOS1 and MEK Inhibition for Improved Immunotherapy Response
    Norgard, Robert J.
    Budhani, Pratha
    O'Brien, Sarah A.
    Xia, Youli
    Egan, Jessica N.
    Flynn, Brianna
    Tagore, Joshua R.
    Seco, Joseph
    Peet, Gregory W.
    Mikucka, Ania
    Wasti, Ruby
    Chan, Li-Chuan
    Hinkel, Melanie
    Martinez-Morilla, Sandra
    Pignatelli, Jeanine
    Trapani, Francesca
    Corse, Emily
    Feng, Di
    Kostyrko, Kaja
    Hofmann, Marco H.
    Liu, Kang
    Kashyap, Abhishek S.
    CANCER RESEARCH COMMUNICATIONS, 2024, 4 (06): : 1548 - 1560
  • [8] Impaired JNK Signaling Cooperates with KrasG12D Expression to Accelerate Pancreatic Ductal Adenocarcinoma
    Davies, Clare C.
    Harvey, Emma
    McMahon, Raymond F. T.
    Finegan, Katherine G.
    Connor, Frances
    Davis, Roger J.
    Tuveson, David A.
    Tournier, Cathy
    CANCER RESEARCH, 2014, 74 (12) : 3344 - 3356
  • [9] Immune mechanisms underlie full therapeutic efficacy of a novel inhibitor of KrasG12D in mouse models of pancreatic ductal adenocarcinoma
    Cheng, Noah
    Kemp, Samantha B.
    Markosyan, Nune
    Sor, Rina
    Kim, Il-Kyu
    Hallin, Jill
    Shoush, Jason
    Quinones, Liz
    Brown, Natalie V.
    Bassett, Jared B.
    Joshi, Nikhil
    Yuan, Salina
    Smith, Molly
    Vostrejs, William P.
    Perez-Vale, Kia Z.
    Kahn, Benjamin
    Mo, Feiyan
    Donahue, Timothy R.
    Radu, Caius G.
    Clendenin, Cynthia
    Christensen, James G.
    Vonderheide, Robert H.
    Stanger, Ben Z.
    CANCER RESEARCH, 2023, 83 (07)
  • [10] ATM loss and KrasG12D cooperate to promote widely metastatic pancreatic ductal adenocarcinoma in mice
    Drosos, Yiannis
    Roys, Kathryn
    Kuliyev, Emin
    McKinnon, Peter
    Sosa-Pineda, Beatriz
    CANCER RESEARCH, 2015, 75
12345