Hyalinizing Clear Cell Carcinoma of the Mandible - A Rare Case Report

Hyalinizing clear cell carcinoma (HCCC), also known as clear cell carcinoma is a rare tumor constituting <= 1% of minor salivary gland tumors. We present here the case of a 48-year-old woman with complaints of pain in the left lower jaw with a surgical history of post-marginal mandibulectomy (lesion being benign). However, the postoperative histopathological reports confirmed clear cell carcinoma of the mandible. Due to delay in presenting, a whole-body positron emission tomography scan was performed and reports have shown no evidence of disease elsewhere in the body. Immunohistochemistry was performed and reports suggested HCCC of salivary gland origin. The patient underwent segmental resection of the mandible along with bilateral modified radical neck dissection and reconstruction of the defect with a free fibula flap. The postoperative period was uneventful. The clinical characteristics, differential diagnosis, surgery, histological, immunohistochemical, and treatment for HCCC were reviewed and discussed.