Anaerobe-Targeted Antibiotic Therapy in the Neonatal Intensive Care Unit

被引：0
|
作者：
Green, Matthew B. [1 ]
Barboza, Alvaro Zevallos [2 ]
Mukhopadhyay, Sagori [2 ,3 ]
Gerber, Jeffrey S. [3 ,4 ]
Morowitz, Michael J. [5 ]
Puopolo, Karen M. [2 ,3 ]
Flannery, Dustin D. [2 ,3 ]
机构：
[1] Rowan Virtua Sch Osteopath Med, Stratford, NJ USA
[2] Childrens Hosp Philadelphia, Div Neonatol, 800 Spruce St, Philadelphia, PA 19107 USA
[3] Univ Penn, Perelman Sch Med, Dept Pediat, 800 Spruce St, Philadelphia, PA 19107 USA
[4] Childrens Hosp Philadelphia, Div Infect Dis, Philadelphia, PA USA
[5] Univ Pittsburgh, Sch Med, Dept Surg, Pittsburgh, PA USA
来源：
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY | 2025年 / 14卷 / 01期
关键词：
anaerobic; antibiotic; bacteria; neonatal; prematurity; NECROTIZING ENTEROCOLITIS; ANTIMICROBIAL THERAPY;
D O I：
10.1093/jpids/piae109
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Anaerobe-targeted antibiotic (ATA) therapy may adversely impact the developing neonatal microbiome. We describe utilization patterns, potential indications, and related outcomes of ATA therapy in neonatal intensive care units across the United States over 13 years. While overall antibiotic use decreased, ATA use was unchanged. Potentially associated indications were inconsistent. We describe the utilization of and indications for anaerobe-targeted antibiotic (ATA) therapy in neonatal intensive care units from 2009 to 2021. We found that while overall antibiotic use decreased, ATA use was unchanged. We identified inconsistencies in potentially associated indications.
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页数：5
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