Toward a functional future for the cognitive neuroscience of human aging

被引：0
|
作者：
Mooraj, Zoya [1 ,2 ,3 ]
Salami, Alireza [4 ,5 ,6 ,7 ,8 ]
Campbell, Karen L. [9 ]
Dahl, Martin J. [1 ,2 ,3 ,10 ]
Kosciessa, Julian Q. [11 ]
Nassar, Matthew R. [12 ,13 ]
Werkle-Bergner, Markus [1 ]
Craik, Fergus I. M. [14 ]
Lindenberger, Ulman [1 ,2 ,3 ]
Mayr, Ulrich [15 ]
Rajah, M. Natasha [16 ,17 ]
Raz, Naftali [1 ,18 ]
Nyberg, Lars [6 ,7 ,19 ]
Garrett, Douglas D. [1 ,2 ,3 ]
机构：
[1] Max Planck Inst Human Dev, Ctr Lifespan Psychol, Lentzeallee 94, D-14195 Berlin, Germany
[2] Max Planck UCL Ctr Computat Psychiat & Ageing Res, Lentzeallee 94, D-14195 Berlin, Germany
[3] Max Planck UCL Ctr Computat Psychiat & Ageing Res, 10-12 Russell Sq, London WC1B 5EH, England
[4] Karolinska Inst, Aging Res Ctr, S-17165 Stockholm, Sweden
[5] Stockholm Univ, S-17165 Stockholm, Sweden
[6] Umea Univ, Umea Ctr Funct Brain Imaging UFBI, S-90187 Umea, Sweden
[7] Umea Univ, Dept Med & Translat Biol, S-90187 Umea, Sweden
[8] Umea Univ, Wallenberg Ctr Mol Med, S-90187 Umea, Sweden
[9] Brock Univ, Dept Psychol, 1812 Sir Isaac Brock Way, St Catharines, ON L2S 3A1, Canada
[10] Univ Southern Calif, Leonard Davis Sch Gerontol, Los Angeles, CA 90089 USA
[11] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, NL-6525 GD Nijmegen, Netherlands
[12] Brown Univ, Robert J & Nancy D Carney Inst Brain Sci, Providence, RI 02912 USA
[13] Brown Univ, Dept Neurosci, 185 Meeting St, Providence, RI 02912 USA
[14] Rotman Res Inst Baycrest, Toronto, ON M6A 2E1, Canada
[15] Univ Oregon, Dept Psychol, Eugene, OR 97403 USA
[16] McGill Univ, Dept Psychiat, Montreal, PQ H3A 1A1, Canada
[17] Toronto Metropolitan Univ, Dept Psychol, Toronto, ON M5B 2K3, Canada
[18] SUNY Stony Brook, Dept Psychol, Stony Brook, NY 11794 USA
[19] Umea Univ, Dept Diagnost & Intervent, Diagnost Radiol, S-90187 Umea, Sweden
来源：
NEURON | 2025年 / 113卷 / 01期
关键词：
BRAIN SIGNAL VARIABILITY; ADULT AGE-DIFFERENCES; REWARD PREDICTION ERRORS; DIFFUSION-MODEL ANALYSIS; LIFE-SPAN; LOCUS-COERULEUS; WORKING-MEMORY; OLDER-ADULTS; INDIVIDUAL-DIFFERENCES; RESTING-STATE;
D O I：
10.1016/j.neuron.2024.12.008
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The cognitive neuroscience of human aging seeks to identify neural mechanisms behind the commonalities and individual differences in age-related behavioral changes. This goal has been pursued predominantly through structural or "task-free"resting-state functional neuroimaging. The former has elucidated the material foundations of behavioral decline, and the latter has provided key insight into how functional brain networks change with age. Crucially, however, neither is able to capture brain activity representing specific cognitive processes as they occur. In contrast, task-based functional imaging allows a direct probe into how aging affects real-time brain-behavior associations in any cognitive domain, from perception to higher-order cognition. Here, we outline why task-based functional neuroimaging must move center stage to better understand the neural bases of cognitive aging. In turn, we sketch a multi-modal, behavior-first research framework that is built upon cognitive experimentation and emphasizes the importance of theory and longitudinal design.
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页码：154 / 183
页数：30
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