Effect of house dust mite sublingual immunotherapy in patients with adult atopic dermatitis with rhinitis

被引：0
|
作者：
Mizuno, Mayuko [1 ]
Imamura, Shinya [1 ,2 ]
Yoshioka, Ai [1 ]
Washio, Ken [1 ,3 ]
Oda, Yoshiko [1 ]
Matsuhara, Hiroki [4 ]
Ohashi-Doi, Katsuyo [4 ]
Fukunaga, Atsushi [1 ,5 ]
机构：
[1] Kobe Univ, Grad Sch Med, Dept Internal Related, Div Dermatol, 7-5-1 Kusunoki Cho,Chuo Ku, Kobe 6500017, Japan
[2] Kobe City Med Ctr West Hosp, Dept Dermatol, Kobe, Hyogo, Japan
[3] Kobe City Nishi Kobe Med Ctr, Dept Dermatol, Kobe, Hyogo, Japan
[4] Torii Pharmaceut Co Ltd, 3-4-1 Nihonbashi Honcho,Chuo Ku, Tokyo 1038439, Japan
[5] Osaka Med & Pharmaceut Univ, Fac Med, Dept Dermatol, Div Med Funct & Morphol Sensory Organs, 2-7 Daigaku Cho, Takatsuki, Osaka 5690801, Japan
来源：
FUTURE SCIENCE OA | 2024年 / 10卷 / 01期
关键词：
allergy immunotherapy; atopic dermatitis; <italic>dermatophagoides farinae</italic>; <italic>dermatophagoides pteronyssinus</italic>; sublingual immunotherapy;
D O I：
10.1080/20565623.2024.2419779
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: Whether house dust mite (HDM) sublingual immunotherapy (SLIT) is effective for the skin symptoms of adult atopic dermatitis (AD) is unclear.Methods: HDM SLIT was added to conventional AD treatment for 10 HDM-sensitized AD patients with rhinitis for 2 years.Results: Seven out of ten enrolled patients completed the study. Eczema Area and Severity Index score was significantly reduced when comparing before treatment and at 24 months follow-up. CD203c ratio in the basophil activation test using HDM extract, skin prick test with HDM extract and Dermatophagoides pteronyssinus/Dermatophagoides farinae specific-IgG4 tended to improve when comparing before treatment and after treatment.Conclusion: HDM SLIT might be a therapeutic option for AD patients with rhinitis who are sensitized to HDM.
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页数：11
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