Metal-Free and Diastereoselective Synthesis of 4-Oxa-δ-Lactams with 2-Aza-3-Silyloxy-1,3-Butadienes and Fluoroalkyl Acylsilanes

被引：0

作者：

Song, Dalu ^{[1
]}

Zhang, Yunxiao ^{[1
]}

He, Xiaoqian ^{[1
]}

Zhou, Gang ^{[1
]}

Zhang, Weilu ^{[1
]}

Shen, Xiao ^{[1
,2
,3
]}

机构：

[1] Wuhan Univ, Inst Adv Studies, Engn Res Ctr Organosilicon Cpds & Mat, Minist Educ, Wuhan 430072, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Fluorine & Nitrogen Chem & Adv Mat, Shanghai 200032, Peoples R China

[3] Wuhan Univ, Shenzhen Res Inst, Shenzhen 518057, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2025年 / 28卷 / 11期

基金：

国家重点研发计划;

关键词：

Fluoroalkylation; 4-Oxo-delta-lactam; Hetero Diels-Alder reaction; Metal-free; Acylsilane; DIELS-ALDER REACTION; BRASSARD DIENE; ALDEHYDES; ACCESS;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report a diastereoselective [4+2] cycloaddition reaction of 2-aza-3-silyloxy-1,3-butadienes and fluoroalkyl acylsilanes for the synthesis of fluoroalkyl 4-oxa-delta-lactams without a metal catalyst or an additive under open-to-air conditions. The reaction features mild conditions, high efficiency and excellent diastereoselectivity, exhibiting a broad substrate scope and good functional group tolerance.

引用

页数：5

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