Broad H3K4me3 domains orchestrate temporal control of gene expression

Spermatogenesis is a highly coordinated developmental process during which precise temporal control of gene expression is crucial. In a recent study published in Cell Research, Lin et al. systematically profiled the epigenomic landscapes of male germ cells across developmental stages and discovered that a histone methyltransferase SETD1B establishes thousands of spermatid-specific broad H3K4me3 domains to ensure temporal transcriptional control during sperm development.