Nickel-catalyzed decarboxylative difluoromethylation and alkylation of alkenes

Herein,we describe a nickel-catalyzed reductive decarboxylative difluoromethylation reaction of alkenes using inexpensive and easy-to-handle difluoroacetic anhydride （DFAA）/pyridine N-oxide reagent system.A variety of C（sp3）-CF2H containing compounds were prepared through a hydrodifluoromethylation process.Besides,various gem–difluoroalkenes bearing CF2H group were synthesized via defluorinative reductive cross-coupling process from trifluoromethyl-substituted alkenes using this new reaction system.Difluoroacetic anhydride has been then extended to other common alkyl anhydrides,and the corresponding hydroalkylation and defluoroalkylation processes have been successfully achieved.This method features broad substrate scope,good functional group tolerance as well as high efficiency.