Molecular architecture of mammalian pyruvate dehydrogenase complex

被引：0

作者：

Maofei Chen ^{[1
,2
]}

Yutong Song ^{[1
,3
]}

Sensen Zhang ^{[1
,2
]}

Yitang Zhang ^{[1
,2
]}

Xudong Chen ^{[1
,2
]}

Minghui Zhang ^{[4
]}

Meng Han ^{[5
]}

Xin Gao ^{[6
,7
]}

Sai Li ^{[1
,3
]}

Maojun Yang ^{[1
,2
,8
,9
]}

机构：

[1] Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University

[2] Ministry of Education Key Laboratory of Protein Science, Tsinghua University

[3] State Key Laboratory of Membrane Biology, Tsinghua University

[4] Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shenzhen University Health Science Center

[5] Protein Research Technology Center, Protein Chemistry and Omics Platform, School of Life Sciences, Tsinghua University

[6] Computer Science Program, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST)

[7] Computational Bioscience Research Center, King Abdullah University of Science and Technology

[8] Cryo-EM Facility Center, Southern University of Science and Technology

[9] Beijing Life Science

来源：

Protein & Cell | 2025年 / 16卷 / 01期

关键词：

D O I：

暂无

中图分类号：

Q55 [酶];

学科分类号：

摘要：

<正>Dear Editor,Pyruvate dehydrogenase complex(PDHc) is a large multienzyme assembly(Mr = 4–10 million Daltons) consisting of three essential components: pyruvate dehydrogenase(E1p), dihydrolipoyl transacetylase(E2p), and dihydrolipoyl dehydrogenase(E3). These three enzymes perform distinct functions sequentially to catalyze the oxidative decarboxylation of pyruvate with formation of nicotinamide adenine dinucleotide(NADH) and acetyl-coenzyme A(Patel and Roche, 1990).

引用

页码：72 / 78

页数：7

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