Therapeutic treatment of hepatitis E virus infection in pigs with a neutralizing monoclonal antibody

被引:0
|
作者
Hrabal, Isabella [1 ]
Aliabadi, Elmira [2 ,3 ]
Reiche, Sven [4 ]
Weber, Saskia [1 ,5 ]
Holicki, Cora M. [1 ,6 ]
Schmid, Laura [1 ,7 ]
Fast, Christine [1 ]
Schroeder, Charlotte [4 ]
Gutjahr, Benjamin [1 ]
Behrendt, Patrick [2 ,8 ,9 ]
Groschup, Martin H. [1 ,10 ]
Eiden, Martin [1 ]
机构
[1] Friedrich Loeffler Inst, Inst Novel & Emerging Infect Dis, Greifswald, Germany
[2] Inst Expt Virol, Ctr Expt & Clin Infect Res, TWINCORE, Hannover, Germany
[3] Helmholz Ctr Infect Res GmbH, Braunschweig, Germany
[4] Friedrich Loeffler Inst, Dept Expt Anim Facil & Biorisk Management, Greifswald, Insel Riems, Germany
[5] Inst Diagnost Virol, Friedrich Loeffler Inst, Greifswald, Insel Riems, Germany
[6] Erasmus MC, Dept Virosci, Rotterdam, Netherlands
[7] Friedrich Loeffler Inst, Inst Mol Virol & Cell Biol, Greifswald, Insel Riems, Germany
[8] Hannover Med Sch, Dept Gastroenterol Hepatol Infect Dis & Endocrinol, Hannover, Germany
[9] German Ctr Infect Res, Partner site Braunschweig Hannover, Braunschweig, Germany
[10] German Ctr Infect Res, Partner Site Hamburg Lubeck Borstel Riems, Greifswald, Insel Riems, Germany
来源
SCIENTIFIC REPORTS | 2025年 / 15卷 / 01期
关键词
Hepatitis E virus; Therapy; Monoclonal antibody; In vitro characterization; Pig model; NEONATAL FC-RECEPTOR; DEPENDENT ENHANCEMENT; WILD BOAR; MOUSE; HEV;
D O I
10.1038/s41598-025-95992-x
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Hepatitis E virus (HEV) poses a significant risk to human health. In Europe, the majority of HEV infection are caused by the zoonotic genotype 3 (HEV-3), which can cause chronic hepatitis E in immunocompromised patients and those with pre-existing liver disease, and may eventually develop into fatal liver cirrhosis. In this study, we examined the effectiveness of a monoclonal antibody (MAb) treatment strategy using a well established HEV-3 pig model with intravenous infection. For this purpose, nine MAbs raised against the viral capsid protein were generated and the neutralizing activities were compared using in vitro assays. The antibody with the highest neutralizing activity, MAb 5F6A1, was selected for an in vivo study in pigs infected with HEV-3. Following the initial infection of pigs with HEV-3, MAb 5F6A1 was administered intravenously one and seven days post-infection. The results suggest MAb 5F6A1 significantly reduced viremia and virus shedding in pigs infected with HEV-3. This study provides significant insight into the dynamics of HEV infection in pigs and highlights the efficacy of MAb based therapy as an option for treating HEV in porcine hosts and, potentially, humans.
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页数:13
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