Insights into phosphate homeostasis regulation by XPR1

被引：0
|
作者：
Bondeson, Daniel P. [1 ]
机构：
[1] UMass Chan Med Sch, Dept Syst Biol, Worcester, MA 01655 USA
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2025年 / 32卷 / 01期
关键词：
D O I：
10.1038/s41594-024-01460-x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
XPR1 is the only annotated phosphate exporter protein in humans. Recent studies provide mechanistic clues to its cellular function; three posit non-export mechanisms to regulate phosphate homeostasis, while six present high-resolution cryo-EM data supporting a bona fide phosphate channel mechanism controlled by intracellular phosphate levels.
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页码：5 / 7
页数：3
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