CHI3L1 mediates radiation resistance in colorectal cancer by inhibiting ferroptosis via the p53/SLC7A11 pathway

被引：0
|
作者：
Ming Jin [1 ]
Hui Liu [1 ]
Zhen Zheng [1 ]
Shuai Fang [2 ]
Yang Xi [3 ]
Kaitai Liu [1 ]
机构：
[1] The Affiliated Lihuili Hospital of Ningbo University,Department of Radiation Oncology
[2] The Affiliated Hospital of Medical School of Ningbo University,Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Health Science Center
[3] Ningbo University,undefined
来源：
Journal of Translational Medicine | / 23卷 / 1期
关键词：
CHI3L1; Radiation resistance; P53; SLC7A11; Colorectal cancer; Ferroptosis;
D O I：
10.1186/s12967-025-06378-6
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [1] NOBILETIN AMELIORATES HEATSTROKE-INDUCED ACUTE LUNG INJURY BY INHIBITING FERROPTOSIS VIA P53/SLC7A11 PATHWAY
    Chen, Hui
    Xie, Weidang
    Peng, Zanling
    Liu, Yanan
    Li, Hongbo
    Huang, Wei
    SHOCK, 2024, 61 (01): : 105 - 111
  • [2] STEAP3 Affects Ovarian Cancer Progression by Regulating Ferroptosis through the p53/SLC7A11 Pathway
    Han, Yi
    Fu, Lei
    Kong, Yan
    Jiang, Changqing
    Huang, Liying
    Zhang, Hualing
    MEDIATORS OF INFLAMMATION, 2024, 2024
  • [3] Brazilin Actuates Ferroptosis in Breast Cancer Cells via p53/SLC7A11/GPX4 Signaling Pathway
    HE Dan
    TAN Xiaoning
    LI Linpei
    GAO Wenhui
    TIAN Xuefei
    ZENG Puhua
    Chinese Journal of Integrative Medicine, 2024, 30 (11) : 1001 - 1006
  • [4] Brazilin Actuates Ferroptosis in Breast Cancer Cells via p53/SLC7A11/GPX4 Signaling Pathway
    He, Dan
    Tan, Xiao-ning
    Li, Lin-pei
    Gao, Wen-hui
    Tian, Xue-fei
    Zeng, Pu-hua
    CHINESE JOURNAL OF INTEGRATIVE MEDICINE, 2024, 30 (11) : 1001 - 1006
  • [5] HTRA1 interacts with SLC7A11 to modulate colorectal cancer chemosensitivity by inhibiting ferroptosis
    Liu, Weiwei
    Liu, Chaoqun
    Xiao, Jun
    Qian, Cheng
    Chen, Zhilin
    Lin, Wandie
    Zhang, Yujie
    Wu, Jianghua
    Zhou, Rui
    Zhao, Liang
    CELL DEATH DISCOVERY, 2024, 10 (01)
  • [6] p53 Activates the Lipoxygenase Activity of ALOX15B via Inhibiting SLC7A11 to Induce Ferroptosis in Bladder Cancer Cells
    Li, Xurui
    Xiong, Wei
    Wang, Yinhuai
    Li, Yijian
    Cheng, Xu
    Liu, Wentao
    LABORATORY INVESTIGATION, 2023, 103 (05)
  • [7] Arbutin alleviates fatty liver by inhibiting ferroptosis via FTO/ SLC7A11 pathway
    Jiang, Tianyu
    Xiao, Yao
    Zhou, Jinfeng
    Luo, Zupeng
    Yu, Lin
    Liao, Qichao
    Liu, Siqi
    Qi, Xinyi
    Zhang, Hao
    Hou, Menglong
    Miao, Weiwei
    Batsaikhan, Batbold
    Damba, Turtushikh
    Liang, Yunxiao
    Li, Yixing
    Zhou, Lei
    REDOX BIOLOGY, 2023, 68
  • [8] Shenshuaifu Granule Attenuates Acute Kidney Injury by Inhibiting Ferroptosis Mediated by p53/ SLC7A11/GPX4 Pathway
    Jin, Xiaoming
    He, Riming
    Lin, Yunxin
    Liu, Jiahui
    Wang, Yuzhi
    Li, Zhongtang
    Liao, Yijiao
    Yang, Shudong
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2023, 17 : 3363 - 3383
  • [9] The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11
    Liu, Tong
    Jiang, Le
    Tavana, Omid
    Gu, Wei
    CANCER RESEARCH, 2019, 79 (08) : 1913 - 1924
  • [10] STAT6 inhibits ferroptosis and alleviates acute lung injury via regulating P53/SLC7A11 pathway
    Yang, Youjing
    Ma, Yu
    Li, Qianmin
    Ling, Yi
    Zhou, Yujia
    Chu, Kaimiao
    Xue, Lian
    Tao, Shasha
    CELL DEATH & DISEASE, 2022, 13 (06)
12345