This study investigates the wind-induced interference effects on a triangular-shaped high-rise building under two distinct wind conditions: laminar flow and turbulent flow. While traditional design standards primarily address wind loads on regular geometries, there is a notable gap in research on the aerodynamic interference effects on irregular high-rise structures. To bridge this gap, Computational Fluid Dynamics (CFD) simulations were conducted and validated against wind tunnel test data using the Spalart–Allmaras Detached Eddy Simulation (DES) turbulence model. The study examines the dynamic response of the building model under both laminar and turbulent wind conditions, focusing on eddy formation, transportation, and dissipation due to viscosity effects. The along-wind and across-wind dynamic responses are analyzed for wind speeds of 50 m/s at a 0° wind incidence angle, comparing the aerodynamic behavior under the two flow regimes. Results indicate that in turbulent conditions, crosswind vortices induce significant aeroelastic effects, leading to resonance when the wind direction is perpendicular to the building’s primary axis. Variations in acceleration provide evidence of the intensity of vortex-induced resonance, particularly under strong turbulent flow conditions. Furthermore, the pressure distribution across four different models is examined to assess the impact of wind interference in both flow regimes. By explicitly considering both laminar and turbulent wind conditions, this study enhances the understanding of wind-induced interference effects on non-conventional high-rise structures, offering critical insights for improved wind-resistant design strategies.