Neoadjuvant immune checkpoint inhibitors for hepatocellular carcinoma

被引：0

作者：

Vinita Akula ^{[1
]}

Lily Chen ^{[1
]}

Yusuf Acikgoz ^{[2
]}

Katherine Klein ^{[1
]}

Betul Gok Yavuz ^{[3
]}

Lokman Cevik ^{[4
]}

Tarik Demir ^{[5
]}

Ashish Manne ^{[2
]}

Ilyas Sahin ^{[6
]}

Ahmed Kaseb ^{[7
]}

Elshad Hasanov ^{[2
]}

机构：

[1] The University of Texas Health Science Center at Houston (UTHealth),Department of Internal Medicine

[2] The Ohio State University Comprehensive Cancer Center,Division of Medical Oncology, Department of Internal Medicine

[3] University of Missouri,Department of Medicine

[4] The Ohio State University Wexner Medical Center,Department of Pathology

[5] Northwestern University,Division of Hematology and Oncology Developmental Therapeutics Institute

[6] University of Florida,Division of Hematology & Oncology, Department of Medicine

[7] The University of Texas MD Anderson Cancer Center,Department of Gastrointestinal Medical Oncology

来源：

npj Precision Oncology | / 9卷 / 1期

关键词：

D O I：

10.1038/s41698-025-00846-4

中图分类号：

学科分类号：

摘要：

Hepatocellular carcinoma (HCC) is the most common type of liver cancer. HCC treatment is challenging; surgical resection is the primary curative treatment for early-stage disease, but recurrence rates are high. Immune checkpoint inhibitors (ICIs) are a promising neoadjuvant treatment that can reduce recurrence rates and mortality after surgery and achieve complete/partial responses. Clinical trials provide strong evidence for the efficacy and safety of ICI monotherapy for neoadjuvant HCC treatment.

引用

共 50 条

[1] Immune checkpoint inhibitors for hepatocellular carcinoma
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[2] Immune checkpoint inhibitors for hepatocellular carcinoma
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[9] Tyrosine kinase inhibitors plus immune checkpoint inhibitors as neoadjuvant therapy for hepatocellular carcinoma: an emerging option?
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[10] Neoadjuvant Immune Checkpoint Inhibitors for Resectable Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
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