Synthesis and Analgesic Activity of Ureas and Imidazolidine-2,4,5-trione Derivatives Containing Adamantane and Monoterpene Fragments

被引：0
|
作者：
Rogozin, P. E. [1 ]
Suslov, E. V. [1 ]
Filippova, A. Yu. [1 ]
Pavlova, A. V. [1 ]
Volcho, K. P. [1 ]
Salakhutdinov, N. F. [1 ]
机构：
[1] Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2025年 / 95卷 / 01期
基金：
俄罗斯科学基金会;
关键词：
adamantane; monoterpenes; analgesic activity;
D O I：
10.1134/S1070363224612808
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
AbstractA series of ureas and substituted parabanic acids containing monoterpene and adamantane fragments were synthesized. It was found that urea containing a (-)-menthone residue, as well as an imidazolidine-2,4,5-trione derivative with a (+)-campholenaldehyde moiety, exhibit analgesic activity.
引用
收藏
页码：23 / 29
页数：7
相关论文
共 19 条
  • [1] A facile synthesis of imidazolidine-2,4,5-trione
    Yang, De-Li
    Li, Jia-Rong
    Lu, Hong-Yan
    Zhang, Pan
    Shi, Da-Xin
    JOURNAL OF CHEMICAL RESEARCH, 2014, (10) : 625 - 626
  • [2] Synthesis and characterization of new polyesters containing imidazolidine-2,4,5-trione rings
    Gaina, C
    Gaina, V
    Cozan, V
    EUROPEAN POLYMER JOURNAL, 2001, 37 (01) : 79 - 84
  • [3] Simple Synthesis of Imidazolidinetrione Derivatives Having Imidazolidine-2,4,5-trione and 2-Thioxo-imidazolidine-4,5-dione Rings
    Lee, Y. -G.
    Jung, D. -I.
    Kim, Y. -H.
    Jeon, E. -H.
    Choi, S. -K.
    Hahn, J. -T.
    Cho, C. -H.
    POLISH JOURNAL OF CHEMISTRY, 2009, 83 (10) : 1765 - 1770
  • [4] Kinetics and mechanism of addition of parabanic acid (imidazolidine-2,4,5-trione) to oxiranes
    Zarzyka-Niemiec, I
    Lubczak, J
    INTERNATIONAL JOURNAL OF CHEMICAL KINETICS, 2003, 35 (02) : 73 - 80
  • [5] Synthesis and antimicrobial activity of sulphamethoxazole-based ureas and imidazolidine-2,4,5-triones
    Kratky, Martin
    Mandikova, Jana
    Trejtnar, Frantisek
    Buchta, Vladimr
    Stolarikova, Jirina
    Vinsova, Jarmila
    CHEMICAL PAPERS, 2015, 69 (08) : 1108 - 1117
  • [6] Synthesis and antimicrobial activity of sulphamethoxazole-based ureas and imidazolidine-2,4,5-triones
    Martin Krátký
    Jana Mandíková
    František Trejtnar
    Vladimír Buchta
    Jiřina Stolaříková
    Jarmila Vinšová
    Chemical Papers, 2015, 69 : 1108 - 1117
  • [7] The crystal structure of 1-methyl-3-(N-methylnitrous amide-N-methylene) imidazolidine-2,4,5-trione
    Xiaolin, Wei
    Jianhui, Zhou
    Jinjun, Geng
    Zhiwei, Wen
    Manyi, Qu
    Xiaoting, Hou
    Ruiqin, Li
    Rui, Feng
    Lukui, Zhao
    Pengbao, Lian
    Jianlong, Wang
    ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 2025,
  • [8] PYRIMIDINES .57. A VERSATILE SYNTHESIS OF PYRIMIDO-[4,5-D]PYRIMIDINE-2,4,5-TRIONE DERIVATIVES
    HIROTA, K
    HUANG, J
    SAJIKI, H
    MAKI, Y
    HETEROCYCLES, 1986, 24 (08) : 2293 - 2298
  • [9] Synthesis of Norabietyl and Nordehydroabietyl Imidazolidine-2,4,5-Triones and Their Activity against Tyrosyl-DNA Phosphodiesterase 1
    Kovaleva, Kseniya S.
    Yarovaya, Olga I.
    Chernyshova, Irina A.
    Zakharenko, Alexandra L.
    Cheresiz, Sergey V.
    Azimirad, Amirhossein
    Pokrovsky, Andrey G.
    Lavrik, Olga I.
    Salakhutdinov, Nariman F.
    MOLBANK, 2023, 2023 (04)
  • [10] Synthesis and anxiolytic activity of 2-aminoadamantane derivatives containing monoterpene fragments
    Kapitsa, I. G.
    Suslov, E. V.
    Teplov, G. V.
    Korchagina, D. V.
    Komarova, N. I.
    Volcho, K. P.
    Voronina, T. A.
    Shevela, A. I.
    Salakhutdinov, N. F.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2012, 46 (05) : 263 - 265
12