In today’s building industry, it is essential to manage increasing structural vibrations resulting from lower damping levels since taller, lighter, and more flexible structures are needed. The purpose of this study is to determine how well tuned liquid dampers, or TLDs, can reduce these vibrations. A 3D frame model with a liner TLD was subjected to a thorough computational study utilizing Finite Element Method (FEM) software under various seismic loading scenarios. The 1989 Loma Prieta Earthquake (PGA = 4.69 g), the 1994 North-ritz Earthquake (PGA = 5.92 g), the 2001 Bhuj Earthquake (PGA = 0.68 g), the 2011 New Zealand Earthquake (PGA = 7.86 g), and the 1995 Kobe Earthquake (PGA = 0.37 g) were the five notable historical earthquake scenarios that were simulated. The analysis includes a five-bay building with 10, 15, 20, 25, and 30 stories. It is situated on flat and sloping ground, with inclination of 15°, 20°, 25°, and 30°. The TLD’s efficiency was assessed using shear force, bending moments, and top-story displacement acceleration. The results demonstrate that TLDs significantly reduce structural vibrations; optimal performance is attained when the TLD is properly positioned at the top story and perfectly tuned to the structure’s associated frequency. Significantly, mistuning led to a significant decrease in damping efficiency, highlighting the vital requirement for accurate tuning. These results highlight TLDs’ potential as a useful tool for improving structural performance and resilience under dynamic loading scenarios. Guidelines for the best use of TLDs in seismic design procedures are provided by this research, which offers insightful information on the development and application of TLDs.