Metabolic-epigenetic rewiring in CD8+ T cells via lactate-dependent histone lactylation

被引：0
|
作者：
Sun, Renqiang [1 ]
Chi, Hongbo [1 ]
机构：
[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
来源：
NATURE IMMUNOLOGY | 2024年 / 25卷 / 11期
关键词：
FATE;
D O I：
10.1038/s41590-024-01991-x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The interplay of metabolites with epigenetic programs influences CD8(+) T cell fate decisions. Here, Raychaudhuri et al. show that lactate-dependent histone lactylation tunes CD8(+) T cell metabolism and function by regulating epigenetic and transcriptional remodeling.
引用
收藏
页码：1980 / 1982
页数：3
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