Ghana’s agricultural sector faces an array of emergent multi-dimensional risks, underscoring the urgency for innovative and holistic approaches. In this regard, effective risk management is essential for stabilizing economies, ensuring food security, alleviating poverty, and nurturing sustainability. This review explores the concept of multi-risk, empirical manifestations, drivers, novel tools for evaluation and management, and implications for Ghana’s economy and ecosystems. It presents compelling case studies showcasing the successes and challenges of multi-risk management. Strategies in Ghanaian agricultural risk management were examined, spotlighting the need for interdisciplinary research, policy coherence, robust communication, innovative technologies, sustainable practices, market diversification, and local knowledge integration. By embracing a unified and cooperative strategy, Ghana can foster a thriving agricultural sector, safeguarding food security and economic prosperity for future generations.