Silver-Catalyzed Synthesis of 5-Amino-4-sulfonyl Pyrazoles from 1,2-Diaza-1,3-dienes

被引：0

作者：

Jaiswal, Arvind Kumar ^{[1
]}

Kushawaha, Ajay Kishor ^{[1
]}

Katiyar, Sarita ^{[1
,2
]}

Ansari, Alisha ^{[1
,2
]}

Bhatt, Hemlata ^{[1
,2
]}

Kant, Ruchir ^{[3
]}

Sashidhara, Koneni V. ^{[1
,2
,4
]}

机构：

[1] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226031, Uttar Pradesh, India

[2] Acad Sci & Innovat Res, Ghaziabad 201002, Uttar Pradesh, India

[3] CSIR Cent Drug Res Inst, Mol & Struct Biol, Lucknow 226031, India

[4] CSIR Cent Drug Res Inst, Sophisticated Analyt Instrument Facil & Res, Lucknow 226031, Uttar Pradesh, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 21期

关键词：

SULFONYL; ALKYNES; IODINE; DESIGN; METAL;

D O I：

10.1021/acs.joc.4c01936

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and dependable synthetic route for 5-amino-4-sulfonyl pyrazoles, which are substantially important in pharmaceuticals, is highly desirable. This work presents a novel cascade reaction for their efficient synthesis. The approach utilizes silver as a catalyst for C(sp2)-H sulfonylation of readily available starting materials 1,2-diaza-1,3-dienes with sulfinate salts, followed by intramolecular cascade cyclization annulation to afford the desired 5-amino-4-sulfonyl pyrazoles in good to excellent yields under mild conditions.

引用

页码：16033 / 16037

页数：5

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