Computational design of protein binders that boost the antitumour efficacy of CAR T cells

被引：0

作者：

Xia, Zhen ^{[1
]}

Xie, Qi ^{[1
]}

机构：

[1] Westlake Univ, Hangzhou, Peoples R China

来源：

NATURE BIOMEDICAL ENGINEERING | 2024年 / 8卷 / 12期

关键词：

HETEROGENEITY; REVEALS;

D O I：

10.1038/s41551-024-01263-x

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We computationally designed protein binders for chimeric antigen receptor (CAR) constructs to target the glioblastoma-associated antigens EGFR and CD276. Compared with standard CAR T cells, CAR T cells with the de novo-designed binders showed enhanced proliferation, cytokine release and resistance to exhaustion, as well as superior antitumour effects in vitro and in vivo.

引用

页码：1521 / 1522

页数：2

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