The Alleviating Mechanism of Camel Milk on Non-alcoholic Fatty Liver Disease in Mice Based on Lipidomics

Objective: To investigate the alleviating mechanism of camel milk on non-alcoholic fatty liver disease (NAFLD) in mice. Methods: Thirty C57BL/6J mice were randomly assigned into three groups: negative control group (NC group)， model group (Mod group) and camel milk group (CaM group). The negative control group was fed control diets， the model and camel milk groups were fed high-fat diets， and camel milk was given daily by gavage to the camel milk group mice. The experiment lasted for 12 weeks， and the NAFLD model was established. The alleviation mechanism of NAFLD in mice by camel milk was investigated by analyzing biochemical indices， liver pathological structure and liver lipidome. Results: With the intervention of camel milk， the body weight， blood glucose and liver index of NAFLD mice were significantly reduced to 31.45 g， 8.85 mmol/mL and 3.98%， respectively(P © 2024 Chinese Institute of Food Science and Technology. All rights reserved.