Innovative approaches in lung tissue engineering: the role of exosome-loaded bioscaffolds in regenerative medicine

被引:0
|
作者
Torkashvand, Mohammad [1 ]
Rezakhani, Leila [2 ,3 ]
Habibi, Zahra [4 ]
Mikaeili, Abdolhamid [5 ]
Rahmati, Shima [6 ]
机构
[1] Univ Tehran, Coll Engn, Tehran, Iran
[2] Kermanshah Univ Med Sci, Hlth Technol Inst, Fertil & Infertil Res Ctr, Kermanshah, Iran
[3] Kermanshah Univ Med Sci, Sch Med, Dept Tissue Engn, Kermanshah, Iran
[4] Shahrekord Univ Med Sci, Hajar Hosp, Clin Res Dev Unit, Shahrekord, Iran
[5] Kermanshah Univ Med Sci, Hlth Technol Inst, Med Biol Res Ctr, Kermanshah, Iran
[6] Shahrekord Univ Med Sci, Canc Res Ctr, Shahrekord, Iran
关键词
lung regeneration; tissue engineering; exosome-loaded scaffolds; organoids; decelullarization; DRUG-DELIVERY; STEM-CELLS; POLYMERIC SCAFFOLDS; MATRIX; DESIGN; DECELLULARIZATION; RECELLULARIZATION; COMMUNICATION; BIOMATERIALS; HOMEOSTASIS;
D O I
10.3389/fbioe.2024.1502155
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Lung diseases account for over four million premature deaths every year, and experts predict that this number will increase in the future. The top cause of death globally is diseases which include conditions like lung cancer asthma and COPD. Treating severe acute lung injury is a complex task because lungs struggle to heal themselves in the presence of swelling inflammation and scarring caused by damage, to the lung tissues. Though achieving lung regeneration, in controlled environments is still an ambition; ongoing studies are concentrating on notable progress, in the field of lung tissue engineering and methods for repairing lung damage. This review delves into methods, for regenerating lungs with a focus on exosome carry bioscaffolds and mesenchymal stem cells among others. It talks about how these new techniques can help repair lung tissue and improve lung function in cases of damage. Also noted is the significance of ex vivo lung perfusion (EVLP), for rejuvenating donor lungs and the healing properties of exosomes in supporting lung regeneration.
引用
收藏
页数:14
相关论文
共 50 条
  • [1] Exosome-loaded decellularized tissue: Opening a new window for regenerative medicine
    Rahmati, Shima
    Khazaei, Mozafar
    Abpeikar, Zahra
    Soleimanizadeh, Arghavan
    Rezakhani, Leila
    JOURNAL OF TISSUE VIABILITY, 2024, 33 (02) : 332 - 344
  • [2] Exosome-loaded scaffolds for regenerative medicine in hard tissues
    Rahmati, Shima
    Khazaei, Mozafar
    Nadi, Akram
    Alizadeh, Morteza
    Rezakhani, Leila
    TISSUE & CELL, 2023, 82
  • [3] Exosomes and exosome-loaded scaffolds: Characterization and application in modern regenerative medicine
    Khazaei, Fatemeh
    Rezakhani, Leila
    Alizadeh, Morteza
    Mahdavian, Elahe
    Khazaei, Mozafar
    TISSUE & CELL, 2023, 80
  • [4] Emerging roles of hyaluronic acid bioscaffolds in tissue engineering and regenerative medicine
    Hemshekhar, Mahadevappa
    Thushara, Ram M.
    Chandranayaka, Siddaiah
    Sherman, Larry S.
    Kemparaju, Kempaiah
    Girish, Kesturu S.
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2016, 86 : 917 - 928
  • [5] Exosome-loaded hydrogels for craniofacial bone tissue regeneration
    Liu, Xiaojie
    Liu, Chang
    Lin, Qingquan
    Shi, Ting
    Liu, Guanying
    BIOMEDICAL MATERIALS, 2024, 19 (05)
  • [6] New Approaches in Stem Cell Technology and Innovative Biomaterials for Tissue Engineering and Regenerative Medicine
    De Bartolo, Loredana
    CURRENT STEM CELL RESEARCH & THERAPY, 2016, 11 (08) : 604 - 604
  • [7] Tissue engineering and regenerative medicine approaches in colorectal surgery
    Mainali, Bigyan B.
    Yoo, James J.
    Ladd, Mitchell R.
    ANNALS OF COLOPROCTOLOGY, 2024, 40 (04) : 336 - 349
  • [8] Emerging nanotechnology approaches in tissue engineering and regenerative medicine
    Kim, Eung-Sam
    Ahn, Eun Hyun
    Dvir, Tal
    Kim, Deok-Ho
    INTERNATIONAL JOURNAL OF NANOMEDICINE, 2014, 9 : 1 - 5
  • [9] Exosome therapeutics for lung regenerative medicine
    Popowski, Kristen
    Lutz, Halle
    Hu, Shiqi
    George, Arianna
    Dinh, Phuong-Uyen
    Cheng, Ke
    JOURNAL OF EXTRACELLULAR VESICLES, 2020, 9 (01)
  • [10] The role of probiotics in tissue engineering and regenerative medicine
    Golchin, Ali
    Ranjbarvan, Parviz
    Parviz, Shima
    Shokati, Amene
    Naderi, Roya
    Rasmi, Yousef
    Kiani, Samaneh
    Moradi, Faezeh
    Heidari, Fahimeh
    Saltanatpour, Zohreh
    Alizadeh, Akram
    REGENERATIVE MEDICINE, 2023, 18 (08) : 635 - 657