A Self-Assembled Nano-Molecular Glue (Nano-mGlu) Enables GSH/H2O2-Triggered Targeted Protein Degradation in Cancer Therapy

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作者
Sun, Jie [1 ,6 ]
Gu, Mingxi [1 ]
Peng, Lvyang [1 ]
Guo, Jing [3 ]
Chen, Peng [1 ,2 ]
Wen, Yalei [3 ]
Feng, Fang [4 ]
Chen, Xiaojuan [5 ]
Liu, Tongzheng [3 ]
Chen, Yongheng [5 ]
Lu, Xiaoyun [3 ]
Gao, Liqian [1 ]
Yao, Shao Q. [2 ]
Yuan, Peiyan [1 ]
机构
[1] School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-Sen University, Shenzhen,518107, China
[2] Department of Chemistry, National University of Singapore, Singapore,117543, Singapore
[3] State Key Laboratory of Bioactive Molecules and Druggability Assessment, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery, Chinese Ministry of Education, School of Pharmacy, Jinan University,
[4] Division of Antitumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai,201203, China
[5] Department of Oncology, NHC Key Laboratory of Cancer Proteomics, State Local Joint Engineering Laboratory for Anticancer Drugs, Xiangya Hospital, Central South University, Changsha,410008, China
[6] Department of Pharmacy, Linyi People’s Hospital, Linyi,276000, China
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