TFA-promoted (hetero)arylation/hydroxylation of quinoxaline-2-one derivatives with electron-rich aromatic compounds

被引：0

作者：

Jatoth, Ramanna ^{[1
]}

Gugulothu, Kishan ^{[1
]}

Ravi, Nidhi ^{[2
]}

Gayathri, Ranamalla ^{[2
]}

Chandrakumar, Shravani Parehosahalli ^{[2
]}

Kumar, K. Shiva ^{[1
,2
]}

机构：

[1] Osmania Univ, Dept Chem, Hyderabad 500007, India

[2] Cent Univ Kerala, Sch Phys Sci, Dept Chem, Kasaragod 671320, Kerala, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2025年 / 23卷 / 02期

关键词：

ONE-POT SYNTHESIS; DIARYLIODONIUM SALTS; ARYLATION; QUINOXALINONES; INDOLES;

D O I：

10.1039/d4ob00882k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal- and solvent-free, one-pot and TFA-promoted method for the construction of hetero/aryl-substituted quinoxalin-2-ones, pyrazin-2(1H)-ones, and pyrimidin-4(3H)-ones is reported. This method involves the reaction of chloro-derivatives of nitrogen heterocycles with electron-rich arenes/heteroarenes, followed by hydroxylation. This protocol is easy to use, providing access to (hetero)aryl-substituted N-heterocycles in good yields.

引用

页码：313 / 317

页数：5

共 12 条

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