All-optics technique for monitoring absolute cerebral blood flow: validation against magnetic resonance imaging perfusion

被引：0
|
作者：
Shoemaker, Leena N. [1 ,2 ,3 ]
Samaei, Saeed [1 ,2 ]
Deller, Graham [1 ,2 ]
Wang, Danny J. J. [4 ]
Milej, Daniel [1 ,2 ]
St. Lawrence, Keith [1 ,2 ]
机构：
[1] Western University, Department of Medical Biophysics, London,ON, Canada
[2] Lawson Health Research Institute, Imaging Program, London,ON, Canada
[3] Western University, School of Kinesiology, London,ON, Canada
[4] University of Southern California, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, Laboratory of FMRI Technology, Los Angeles,CA, United States
来源：
Neurophotonics | 2024年 / 11卷 / 04期
关键词：
Significance: The ability to monitor cerebral blood flow (CBF) at the bedside is essential to managing critical-care patients with neurological emergencies. Diffuse correlation spectroscopy (DCS) is ideal because it is non-invasive; portable; and inexpensive. We investigated a near-infrared spectroscopy (NIRS) approach for converting DCS measurements into physiological units of blood flow. Aim: Using magnetic resonance imaging perfusion as a reference; we investigated the accuracy of absolute CBF measurements from a bolus-tracking NIRS method that used transient hypoxia as a flow tracer and hypercapnia-induced increases in CBF measured by DCS. Approach: Twelve participants (7 female; 28 ± 6 years) completed a hypercapnia protocol with simultaneous CBF recordings from DCS and arterial spin labeling (ASL). Nine participants completed the transient hypoxia protocol while instrumented with time-resolved NIRS. The estimate of baseline CBF was subsequently used to calibrate hypercapnic DCS data. Results: Moderately strong correlations at baseline (slope = 0.79 and R2 = 0.59) and during hypercapnia (slope = 0.90 and R2 = 0.58) were found between CBF values from calibrated DCS and ASL (range 34 to 85 mL/100 g/ min). Conclusions: Results demonstrated the feasibility of an all-optics approach that can both quantify CBF and perform continuous perfusion monitoring. © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication; including its DOI;
D O I：
10.1117/1.NPh.11.4.045002
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