One-pot enantioselective synthesis of Chiral phenyllactic acids by combining stereocomplementary D- and L-lactate dehydrogenases with multi-enzyme expression fine-tuning

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作者
Chen, Qijia [1 ,2 ]
Cheng, Shuangshuang [1 ]
Zhang, Xiaohe [1 ]
Zhang, Sisi [1 ]
Zhou, Xiaolei [1 ]
Jia, Zhenhua [3 ]
Hao, Jianxiong [1 ,2 ]
机构
[1] College of Food Science and Biology, Hebei University of Science and Technology, Shijiazhuang,050018, China
[2] Fermentation Technology Innovation Center of Hebei Province, Hebei University of Science and Technology, Shijiazhuang,050018, China
[3] Biology Institute, Hebei Academy of Sciences, Shijiazhuang,050051, China
关键词
We thank Assoc. Prof. Xi Chen from Tianjin Institute of Industrial Biotechnology; Chinese Academy of Sciences for helpful discussions and constructive suggestions. This work was supported by the National Natural Science Foundation of China (22001056); the Key R&D Plan of Hebei Province (22372801D); the Natural Science Foundation of Hebei Province (B2020208050) and Open Funding Project of Fermentation Technology Innovation Center of Hebei Province. All authors have seen the manuscript and there are no other manuscripts that have been submitted for publication with related work. This manuscript is submitted exclusively to International Journal of Biological Macromolecules.We thank Assoc. Prof. Xi Chen from Tianjin Institute of Industrial Biotechnology; Chinese Academy of Sciences for helpful discussions and constructive suggestions. This work was supported by the National Natural Science Foundation of China ( 22001056 ); the Key R&D Plan of Hebei Province ( 22372801D ); the Natural Science Foundation of Hebei Province ( B2020208050 ) and Open Funding Project of Fermentation Technology Innovation Center of Hebei Province;
D O I
10.1016/j.ijbiomac.2024.135133
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