The role of immune abnormality in depression and cardiovascular disease
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作者:
RuHui LIU
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机构:
Department of Cardiology, Tongji Hospital, Tongji University School of MedicineDepartment of Cardiology, Tongji Hospital, Tongji University School of Medicine
RuHui LIU
[1
]
JiangQi PAN
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Department of Cardiology, Tongji Hospital, Tongji University School of MedicineDepartment of Cardiology, Tongji Hospital, Tongji University School of Medicine
JiangQi PAN
[1
]
XianE TANG
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机构:
Department of Cardiology, Tongji Hospital, Tongji University School of MedicineDepartment of Cardiology, Tongji Hospital, Tongji University School of Medicine
XianE TANG
[1
]
Bing LI
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机构:
Department of Hematology,Tongji Hospital, Tongji University School of MedicineDepartment of Cardiology, Tongji Hospital, Tongji University School of Medicine
Bing LI
[2
]
ShangFeng LIU
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机构:
Department of Stomatology,Huashan Hospital,FudanDepartment of Cardiology, Tongji Hospital, Tongji University School of Medicine
ShangFeng LIU
[3
]
WenLin MA
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机构:
Department of Cardiology, Tongji Hospital, Tongji University School of MedicineDepartment of Cardiology, Tongji Hospital, Tongji University School of Medicine
WenLin MA
[1
]
机构:
[1] Department of Cardiology, Tongji Hospital, Tongji University School of Medicine
[2] Department of Hematology,Tongji Hospital, Tongji University School of Medicine
[3] Department of Stomatology,Huashan Hospital,Fudan
Depression and cardiovascular disease(CVD) are both highly prevalent disorders, and some evidence shows that there is a 'vicious cycle' linking major depression and CVD. There is also growing evidence that immune abnormalities underpin the common pathophysiology of both CVD and major depression. The abnormalities include the following: abnormal levels of inflammatory markers, such as interleukin-6(IL-6), interleukin-1β(IL-1β), tumor necrosis factor a(TNF-a) and interleukin-12(IL-12); increased acute phase proteins, such as C-reactive protein, fibrinogen and haptoglobin; and abnormal complement factors. The findings show that major depression and CVD patients have greater immune abnormalities, which may increase depressive symptoms and cardiovascular pathological changes, and that there may be a bidirectional relationship, therefore more prospective studies are needed to draw conclusions.