Synthesis of tritiated N-[4-(2,4-diaminopteridine-6-methyl)-3,4-dihydro-2H-1,4- benzothiazine-7-carbonyl]-L-homo glutamic acid (MX-68)

被引：0
|
作者：
Matsuoka, Hiroharu [1 ]
Kuroki, Toshio [1 ]
Yano, Keiichi [1 ]
Takeda, Yasuhisa [1 ]
机构：
[1] Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd., 1-135 Komakado, Gotemba, Shizuoka 412, Japan
来源：
Journal of Labelled Compounds and Radiopharmaceuticals | 1997年 / 39卷 / 05期
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：363 / 368
相关论文
共 50 条
  • [1] Synthesis of tritiated N-[4-(2,4-diaminopteridine-6-methyl)-3,4-dihydro-2H-1,4-benzothiazine-7-carbonyl]-L-homo glutamic acid (MX-68)
    Matsuoka, H
    Kuroki, T
    Yano, K
    Takeda, Y
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1997, 39 (05): : 363 - 368
  • [2] Synthesis of Tritiated N-[4-(2,4-Diaminopteridine-6-Methyl)- 3,4- Dihydro-2H-1,4-Benzothiazine-7-Carbonyl]$ MIN@L- Homo Glutamic Acid (MX-68)
    Matsuoka, H.
    Kuroki, T.
    Yano, K.
    Takeda, Y.
    Journal of Labelled Compounds and Radiopharmaceuticals, 39 (05):
  • [3] Carrier-mediated hepatobiliary transport of a novel antifolate, N-[4-[(2,4-diamminopteridine-6-yl) methyl]-3,4-dihydro-2H-1,4-benzothiazin-7-yl]carbonyl-L- homoglutamic acid, in rats
    Han, YH
    Kato, Y
    Watanabe, Y
    Terao, K
    Asoh, Y
    Sugiyama, Y
    DRUG METABOLISM AND DISPOSITION, 2001, 29 (04) : 394 - 400
  • [4] Synthesis of substituted 4-(3-alkyl-1,2,4-oxadiazol-5-ylmethyl)-3,4-dihydro-2H-1,4-benzoxazines and 4-(1H-benzimidazol-2-ylmethyl)-3,4-dihydro-2H-1,4-benzoxazines
    Mizar, Pushpak
    Myrboh, Bekington
    TETRAHEDRON LETTERS, 2006, 47 (44) : 7823 - 7826
  • [5] The design of efficient and selective routes to pyridyl analogues of 3-oxo-3,4-dihydro-2H-1,4-(benzothiazine or benzoxazine)-6-carbaldehydes
    Brooks, Gerald
    Dabbs, Steven
    Davies, David T.
    Hennessy, Alan J.
    Jones, Graham E.
    Markwell, Roger E.
    Miles, Timothy J.
    Owston, Nathan A.
    Pearson, Neil D.
    Peng, Tony W.
    TETRAHEDRON LETTERS, 2010, 51 (38) : 5035 - 5037
  • [6] Synthesis and biological activity of Na-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-propargylamino]phenyl-acetyl]-L-glutamic acid
    Kusakiewicz-Dawid, A
    Bugaj, M
    Dzik, JM
    Golos, B
    Winska, P
    Pawelczak, K
    Rzeszotarska, B
    Rode, W
    ACTA BIOCHIMICA POLONICA, 2002, 49 (01) : 197 - 203
  • [7] NOVEL AND POTENT ALDOSE REDUCTASE INHIBITORS - 4-BENZYL-3,4-DIHYDRO-3-OXO-2H-1,4-BENZOTHIAZINE-2-ACETIC AND 4-(BENZOTHIAZOL-2-YLMETHYL)-3,4-DIHYDRO-3-OXO-2H-1,4-BENZOTHIAZINE-2-ACETIC ACID-DERIVATIVES
    AOTSUKA, T
    HOSONO, H
    KURIHARA, T
    NAKAMURA, Y
    MATSUI, T
    KOBAYASHI, F
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1994, 42 (06) : 1264 - 1271
  • [8] Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents
    Gangjee, A
    Lin, X
    Kisliuk, RL
    McGuire, JJ
    JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (23) : 7215 - 7222
  • [9] SYNTHESIS OF N-([2-([(2-AMINO-3,4-DIHYDRO-4-OXO-6-PTERIDINYL)METHYL]AMINO)-5-PYRAZINYL]CARBONYL)-L-GLUTAMIC ACID (2',5'-DIAZAFOLIC ACID
    NAKAHARA, Y
    SEKIKAWA, I
    KAKIMOTO, S
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1975, 12 (05) : 1073 - 1074
  • [10] SYNTHESIS OF N-[4-[2-(2,4-DIAMINO-1,6-DIHYDRO-6-OXO-5-PYRIMIDINYL)-ETHYLAMINO]BENZOYL]-L-GLUTAMIC ACID - AN ACYCLIC ANALOG OF 5,6,7,8-TETRAHYDROFOLIC ACID
    KELLEY, JL
    MCLEAN, EW
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1990, 27 (02) : 459 - 461
12345