Preparation of an Aminoxyl Analog of the Anticancer Agent Miltefosine

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Sosnovsky, George [1 ]
Lukszo, Jan [1 ]
Brasch, Robert C. [1 ]
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[1] NIH, Natl. Inst. Allerg. and Infect. Dis., Laboratory of Molecular Structure, 12441 Parklawn Drive, Rockville, MD 20852, United States
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The synthesis and a few properties of hexadecyl 2-[N,N-dimethyl-N-(2,2,6,6-tetramethyl-1-oxyl-piperidin-4-yl)ammonio] ethyl phosphate are described. This compound is a spin labeled analog of the antineoplastic drug hexadecylphosphocholine (Miltefosine).
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页码:888 / 890
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