Microfabricated microneedles for transdermal drug delivery

被引：0
|
作者：
Prausnitz, Mark R. [1 ]
McAllister, Devin V. [1 ]
Kaushik, Shilpa [1 ]
Patel, Parul N. [1 ]
Mayberry, Jennifer L. [1 ]
Allen, Mark G. [1 ]
机构：
[1] Schools Chem., Biomed. Elec. C., Georgia Institute of Technology, Atlanta, GA, United States
来源：
American Society of Mechanical Engineers, Bioengineering Division (Publication) BED | 1999年 / 42卷
关键词：
Controlled drug delivery - Electron microscopy - Neurology - Optical microscopy - Skin - Sterilization (cleaning) - Tissue;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The mechanical and transport-enhancing properties of microneedles were examined. Microneedle arrays were inserted into epidermis and transdermal transport of calcein or fluorescein-labeled BSA was determined by spectrofluorimetry. Following this, microneedles were examined to determine if any breakage occurred during insertion and removal. It was observed that the microneedles are mechanically strong, able to increase transdermal transport by more than four orders of magnitude in vitro, and do not cause pain in human subjects.
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页码：89 / 90
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