Microwave assisted synthesis of 1,5-disubstituted hydantoins and thiohydantoins in solvent-free conditions

被引：0
|
作者：
Paul, S. [1 ]
Gupta, M. [1 ]
Gupta, R. [1 ]
Loupy, A. [2 ]
机构：
[1] Department of Chemistry, University of Jammu, Jammu-180 006, India
[2] Laboratoire des Réactions Sélectives sur Supports, CNRS UMR 8615, Université Paris-Sud, 91405, Orsay, France
来源：
Synthesis | 2002年 / 01期
关键词：
Microwaves; -; Solvents; Urea;
D O I：
10.1055/s-2002-19308
中图分类号：
学科分类号：
摘要：
1,5-Disubstituted hydantoins/thiohydantoins 3a-p have been synthesized in 81-95% yield by a microwave-promoted solvent-free condensation of arylglyoxals 1 and phenylurea/thiourea 2 using PPE as a reaction mediator. This method can be extended towards the parallel synthesis of 3. The workup is simple and involves treatment with ice-cold water.
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页码：75 / 78
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