A Label-Free Detection of Biomolecules Using Micromechanical Biosensors

被引：0

作者：

Meisam Omidi ^{[1
]}

MAMalakoutian ^{[2
]}

Mohammadmehdi Choolaei ^{[3
]}

FOroojalian ^{[1
]}

FHaghiralsadat ^{[1
]}

FYazdian ^{[1
]}

机构：

[1] Faculty of New Science and Technology,University of Tehran

[2] Department of Electrical and Computer Engineering,University of Tehran

[3] Department of Chemical Engineering,South Tehran Branch,Islamic Azad

来源：

Chinese Physics Letters | 2013年 / 30卷 / 06期

关键词：

D O I：

暂无

中图分类号：

TP212.3 [生物传感器、医学传感器];

学科分类号：

摘要：

A Microcantilevers resonator is used to detect a protein biomarker called prostate specific antigen(PSA),which is associated with prostate cancer.Different concentrations of PSA in a buffer solution are detected as a function of deflection of the beams.For this purpose,we use a surface micromachined,antibody-coated polycrystalline silicon micromechanical cantilever beam.Cantilevers have mass sensitivities of the order of 10-17g/Hz,which result from their small mass.This matter allows them to detect an immobilized antibody monolayer corresponding to a mass of about 70fg.With these devices,concentrations as low as 150fg/mL,or 4.5 fM,could be detected from the realistic samples.

引用

页码：236 / 239

页数：4

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