A thermodynamic model of the REM–NREM sleep cycle

被引：0

作者：

Sun, Haeun ^{[1
]}

Ishbulatov, Yurii ^{[2
,3
]}

Karavaev, Anatoly ^{[2
,3
]}

Zakharov, Denis ^{[4
]}

Zaikin, Alexey ^{[4
,5
]}

机构：

[1] Queen Square Institute of Neurology, University College London, Queen Square, London,WC1N 1PA, United Kingdom

[2] Saratov State University, Astrakhanskaya 83, Saratov,410012, Russia

[3] Saratov Branch of the Institute of Radio Engineering and Electronics of Russian Academy of Sciences, Zelyonaya 38, Saratov,410019, Russia

[4] Institute for Cognitive Neuroscience, University Higher School of Economics, 20 Myasnitskaya, Moscow,101000, Russia

[5] Department of Mathematics and Institute for Women's Health, University College London, Gower Street, London,WC1E 6BT, United Kingdom

来源：

Chaos, Solitons and Fractals | 2025年 / 190卷

关键词：

Sleep research;

D O I：

10.1016/j.chaos.2024.115732

中图分类号：

学科分类号：

摘要：

Although many models explain the spontaneous alternation between two distinct sleep states, Rapid Eye Movement (REM) and Non-Rapid Eye Movement (NREM), new empirical evidence has accumulated regarding consistent temperature changes during sleep stage transitions in small animals. The temperature dependence of neuro-excitability and low-frequency (≤4 Hz) neuronal activity has also been investigated theoretically and experimentally. Based on these phenomena, we constructed a stochastic thermodynamic model of the ultradian sleep rhythm. The model was validated through simulation, demonstrating statistical properties that align with experimental data from rats. This model would provide new insights into the mechanisms behind the REM cycle and can be applied in new therapies for sleep disorders. © 2024 The Authors

引用

共 50 条

[1] Relationships between REM and NREM in the NREM-REM sleep cycle: a review on competing concepts
Le Bon, Olivier
[J]. SLEEP MEDICINE, 2020, 70 : 6 - 16
[2] EFFECT OF INTERVENING WAKEFULNESS ON NREM REM SLEEP CYCLE
BREZINOVA, V
[J]. ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1973, 35 (04): : 415 - 415
[3] Correlations using the NREM-REM sleep cycle frequency support distinct regulation mechanisms for REM and NREM sleep
Le Bon, O
Staner, L
Rivelli, SK
Hoffmann, G
Pelc, I
Linkowski, P
[J]. JOURNAL OF APPLIED PHYSIOLOGY, 2002, 93 (01) : 141 - 146
[4] An Asymmetrical Hypothesis for the NREM-REM Sleep Alternation-What Is the NREM-REM Cycle?
Le Bon, Olivier
[J]. FRONTIERS IN NEUROSCIENCE, 2021, 15
[5] REM-NREM SLEEP CYCLE AND WAKING OCULOMOTOR COORDINATION
BERGER, RJ
WALKER, JM
[J]. PSYCHOPHYSIOLOGY, 1972, 9 (01) : 109 - &
[6] MOTOR BEHAVIOR DURING SLEEP AND THE REM-NREM CYCLE
SCHULZ, H
KLINK, J
POLLMACHER, T
[J]. JOURNAL OF INTERDISCIPLINARY CYCLE RESEARCH, 1986, 17 (02): : 153 - 154
[7] EFFECTS OF SLEEP INTERRUPTION ON REM-NREM CYCLE IN NOCTURNAL HUMAN SLEEP
MIYASITA, A
FUKUDA, K
INUGAMI, M
[J]. ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1989, 73 (02): : 107 - 116
[8] RENIN AS A BIOLOGICAL MARKER OF THE NREM-REM SLEEP CYCLE - EFFECT OF REM-SLEEP SUPPRESSION
BRANDENBERGER, G
CHARIFI, C
MUZET, A
SAINI, J
SIMON, C
FOLLENIUS, M
[J]. JOURNAL OF SLEEP RESEARCH, 1994, 3 (01) : 30 - 35
[9] Neurobiology of REM and NREM sleep
McCarley, Robert W.
[J]. SLEEP MEDICINE, 2007, 8 (04) : 302 - 330
[10] REM AND NREM SLEEP MENTATION
McNamara, Patrick
Johnson, Patricia
McLaren, Deirdre
Harris, Erica
Beauharnais, Catherine
Auerbach, Sanford
[J]. DREAMS AND DREAMING, 2010, 92 : 69 - 86

← 1 2 3 4 5 →