Degradation behavior of chitosan-fiber/calcium phosphate cement composite for artificial bone

被引：0
|
作者：
Lian Q. [1 ,2 ]
Li D. [1 ]
Wang Z. [3 ]
Li A. [1 ,2 ]
Jin Z. [1 ,4 ]
Wang J. [1 ,2 ]
机构：
[1] State Key Lab for Manufacturing Systems Engineering, Xi'an Jiaotong University
[2] Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi'an Jiaotong University
[3] Xijing Hospital, The Fourth Military Medical University
[4] Institute of Medical and Biological Engineering, University of Leeds
来源：
Jixie Gongcheng Xuebao/Journal of Mechanical Engineering | 2010年 / 46卷 / 05期
关键词：
Artificial bone; Calcium phosphate bone cement; Chitosan fiber; Composite; Degradation;
D O I：
10.3901/JME.2010.05.110
中图分类号：
学科分类号：
摘要：
To improve the biodegradability of self-setting calcium phosphate bone cement (CPC) adding chitosan fibers (CF) is proposed. The degradability of CF/CPC composite artificial bone is reasearched on the basis of single biomaterial equal-degradation- rate hypothesis and the canine condyle defect repairing experiment. Theoretical analysis finds that the existence of fiber makes the degradation function of CF/CPC artificial bone quadratic rather than linear, and the degradation ratio can be controlled by changing CF content in composite artificial bone. In vivo experiment shows that the remainder law of artificial bone is one of high-order functions, similar to the ideal remainder curve for bone tissue engineering scaffold. Higher degradation rate of CF than CPC leads to the formation of macroporous structure inside the CF/CPC artificial bone, which further promotes new bone growth and bone reconstruction, and by regulating the CF content, the degradation rate of CF/CPC artificial bone can well match the bone regeneration. © 2010 Journal of Mechanical Engineering.
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页码：110 / 115
页数：5
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