Anti-obesity Effect and Mechanism of Konjac Mannooligosaccharides

被引：1
|
作者：
Wen, Yongping [1 ,2 ]
Zhu, Di [1 ]
Sun, Jian [2 ]
Yan, Qiaojuan [3 ]
Jiang, Zhengqiang [1 ]
机构：
[1] College of Food Science and Nutritional Engineering, China Agricultural University, Beijing,100083, China
[2] Meng Niu Hi-Tech Dairy (Beijing) Co. Ltd., Beijing,101107, China
[3] College of Engineering, China Agricultural University, Beijing,100083, China
来源：
Shipin Kexue/Food Science | 2020年 / 41卷 / 05期
关键词：
Objective: To evaluate the inhibitory effect of konjac mannooligosaccharides (KMOS) on obesity and chronic inflammation in high-fat diet (HFD)-induced obese mice and to decipher the underlying molecular mechanisms. Methods: Ten-week-old healthy male C57BL/6J mice were randomly divided into 7 groups. After 12 weeks of continuous feeding; body mass; body fat; blood lipids; and oxidative stress indicators were detected. The indicators associated with lipid metabolism and their gene expression in adipose and liver tissues were analyzed. Results: KMOS effectively reduced body mass by 36.36% and body fat mass by 52.13%; improved blood lipid abnormality; and significantly inhibited the release of inflammatory factors and increased antioxidant enzyme activities (P © 2020; China Food Publishing Company. All right reserved;
D O I：
10.7506/spkx1002-6630-20190926-323
中图分类号：
学科分类号：
摘要：
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页码：115 / 121
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