Decellularized extracellular matrix for organoid and engineered organ culture

被引：0
|
作者：
Guo, Xiaoxu [1 ]
Liu, Boxun [2 ]
Zhang, Yi [2 ]
Cheong, Sousan [1 ]
Xu, Tao [3 ,4 ]
Lu, Feng [1 ]
He, Yunfan [1 ]
机构：
[1] The Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangdong, Guangzhou, China
[2] Research and Development Department, Huamei Biotech Co. Ltd., Shenzhen, China
[3] Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, China
[4] Bio-intelligent Manufacturing and Living Matter Bioprinting Center, Research Institute of Tsinghua University in Shenzhen, Tsinghua University, Shenzhen, China
来源：
Journal of Tissue Engineering | 2024年 / 15卷
关键词：
The repair and regeneration of tissues and organs using engineered biomaterials has attracted great interest in tissue engineering and regenerative medicine. Recent advances in organoids and engineered organs technologies have enabled scientists to generate 3D tissue that recapitulate the structural and functional characteristics of native organs; opening up new avenues in regenerative medicine. The matrix is one of the most important aspects for improving organoids and engineered organs construction. However; the clinical application of these techniques remained a big challenge because current commercial matrix does not represent the complexity of native microenvironment; thereby limiting the optimal regenerative capacity. Decellularized extracellular matrix (dECM) is expected to maintain key native matrix biomolecules and is believed to hold enormous potential for regenerative medicine applications. Thus; it is worth investigating whether the dECM can be used as matrix for improving organoid and engineered organs construction. In this review; the characteristics of dECM and its preparation method were summarized. In addition; the present review highlights the applications of dECM in the fabrication of organoids and engineered organs. © The Author(s) 2024;
D O I：
10.1177/20417314241300386
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