A comparative evaluation between new ternary zirconium alloys as alternative metals for orthopedic and dental prosthetic devices

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[1] Shyti, Genti

[2] Rosalbino, Francesco

[3] Macciò, Daniele

[4] Scarabelli, Linda

[5] Quarto, Rodolfo

[6] Giannoni, Paolo

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Giannoni, P. (paolo.giannoni@unige.it) | 1600年 / Wichtig Publishing Srl卷 / 37期

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Purpose: We assessed in vitro the corrosion behavior and biocompatibility of four Zr-based alloys (Zr97.5 Nb1.5VM1.0; VM; valve metal: Ti; Mo; W; Ta; at%) to be used as implant materials; comparing the results with grade-2 titanium; a biocompatible metal standard. Methods: Corrosion resistance was investigated by open circuit potential and electrochemical impedance spectroscopy measurements as a function of exposure time to an artificial physiological environment (Ringer's solution). Human bone marrow stromal cells were used to evaluate biocompatibility of the alloys and their influence on growth kinetics and cell osteogenic differentiation through histochemical and gene expression analyses. Results: Open circuit potential values indicated that Zr-based alloys and grade-2 Ti undergo spontaneous passivation in the simulated aggressive environment. High impedance values for all samples demonstrated improved corrosion resistance of the oxide film; with the best protection characteristics displayed by Zr97.5 Nb1.5Ta1.0. Cells seeded on all surfaces showed the same growth kinetics; although matrix mineralization and alkaline phosphatase activity were maximal on Zr97.5 Nb1.5Mo1.0 and Zr97.5 Nb1.5Ta1.0. Markers of ongoing proliferation; however; such as podocalyxin and CD49f; were still overexpressed on Zr97.5Mo1.0Nb1.5even upon osteoinduction. No relevant effects were noted for he CD146-expressing population of bone progenitors. Nonetheless; the presence of a more differentiated cell population on Zr97.5Nb1.5Ta1.0 samples was inferable by comparing mineralization data and transcript levels of osteogenic markers (osteocalcin; osteopontin; bone sialoprotein; and RUNX2). Conclusions: The combination of passivation; corrosion resistance and satisfactory biotolerance to bone progenitors make the Zr-based alloys promising implant materials. Among those we tested; Zr97.5Nb1.5Ta1.0 seems to be the most appealing. © 2014 Wichtig Publishing;

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共 6 条

[1] A comparative evaluation between new ternary zirconium alloys as alternative metals for orthopedic and dental prosthetic devices
Shyti, Genti
Rosalbino, Francesco
Maccio, Daniele
Scarabelli, Linda
Quarto, Rodolfo
Giannoni, Paolo
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 2014, 37 (02): : 149 - 164
[2] Corrosion behavior of new ternary zirconium alloys as alternative materials for biomedical applications
Rosalbino, F.
Maccio, D.
Scavino, G.
Saccone, A.
MATERIALS AND CORROSION-WERKSTOFFE UND KORROSION, 2015, 66 (10): : 1125 - 1132
[3] EVALUATION OF UNIONS BETWEEN CASTING DENTAL ALLOYS AND EMBEDDED METALS
TSUKA, T
HAMADA, T
YAMADA, S
JOURNAL OF DENTAL RESEARCH, 1979, 58 : 1289 - 1289
[4] Development of a new dental drained alloy alternative to traditional alloys based on precious metals.
Caballero, A
Oppeltz, N
Leon, S
JOURNAL OF DENTAL RESEARCH, 1996, 75 (05) : 1320 - 1320
[5] Evaluation of a New Titanium-Zirconium Dental Implant: A Biomechanical and Histological Comparative Study in the Mini Pig
Gottlow, Jan
Dard, Michel
Kjellson, Fred
Obrecht, Marcel
Sennerby, Lars
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, 2012, 14 (04) : 538 - 545
[6] COMPARATIVE-ANALYSIS OF 2 ELECTROCHEMICAL TECHNIQUE FOR EVALUATION OF GALVANIC CORROSION BETWEEN IMPLANTS AND DENTAL ALLOYS
GROSGOGEAT, B
LISSAC, M
BRUGIRARD, J
DALARD, F
RECLARU, L
JOURNAL OF DENTAL RESEARCH, 1995, 74 (03) : 938 - 938

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