The Ameliorative Effect of Polyphenol Extract from Sprouting Mung Bean on Glycolipid Metabolism in Type 2 Diabetic Mice

被引：0
|
作者：
Shen X. [1 ,2 ]
Jiang X. [2 ]
Xu Q. [2 ]
Zhang D. [2 ]
机构：
[1] 'Food Processing Research Institute, Heilongjiang Academy of Agricultural Sciences, Heilongjiang Province Key Laboratory of Food Processing, Heilongjiang Province Engineering Research Center of Whole Grain Nutritious Food
[2] Harbin 150086 'Heilongjiang Bayi Agricultural Reclamation University, Heilongjiang, Daqing
来源：
Journal of Chinese Institute of Food Science and Technology | 2023年 / 23卷 / 06期
关键词：
blood glucose; blood lipids; germinated mung bean polyphenols; liver tissue; type II diabetes mellitus;
D O I：
10.16429/j.1009-7848.2023.06.015
中图分类号：
学科分类号：
摘要：
Objective: To investigate the improvement of glycolipid metabolism in mice with type 2 diabetes mellitus (T2DM) induced by polyphenol extract from mung bean sprout. Methods; C57BL/6 mice were randomly divided into normal control group, model group, high, medium and low dose groups of germinated mung bean polyphenol extract and positive control group. A mouse model of type 2 diabetes was established by high fat diet combined with intraperitoneal injection of Streptozotocin (STZ). After continuous gavage for 5 weeks, fasting blood glucose, glucose tolerance, organ index, blood lipid level and liver morphology were measured. Results; during the experiment, compared with the model group, the polyphenol extract of germinated mung bean could reduce the fasting blood glucose and significantly improve the glucose tolerance of mice (P<0.01); Improve the concentration of serum lipid indexes (TC, TG, LDL-C, HDL-C) in T2DM mice (P<0.01); The activity of ALT and AST in serum of mice was reduced, and the morphology of liver tissue in STZ induced diabetic mice was repaired. Conclusion; a certain dose of germinated mung bean polyphenols extract can effectively improve the symptoms of hyperglycemia and dyslipidemia in type 2 diabetic mice. © 2023 Chinese Institute of Food Science and Technology. All rights reserved.
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页码：132 / 139
页数：7
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