Novel N-heterocyclic carbene silver(I) complexes: Synthesis, structural characterization, antimicrobial and cytotoxicity potential studies

被引：0

作者：

Karaca, Emine Ozge ^{[1
]}

Mizrak, Ebru ^{[2
]}

Gurbuz, Nevin ^{[1
,2
,3
]}

Cetinkaya, Erdem ^{[4
]}

Karci, Huseyin ^{[2
]}

Dundar, Muhammed ^{[5
]}

Ozdemir, Ilknur ^{[2
,3
]}

Koc, Ahmet ^{[6
]}

Ozdemi, Ismail ^{[1
]}

Koko, Waleed ^{[7
]}

Al-Hazmy, Sadeq M. ^{[8
]}

Hamdi, Naceur ^{[9
]}

机构：

[1] Inonu Univ Catalyst Res, Applicat Ctr, TR-44280 Malatya, Turkiye

[2] Inonu Univ Drug Applicat, Res Ctr, TR-44280 Malatya, Turkiye

[3] Inonu Univ, Fac Arts & Sci, Dept Chem, TR-44280 Malatya, Turkiye

[4] Univ Hlth Sci, Antalya Training & Res Hosp, Dept Otorhinolaryngol, TR-07100 Antalya, Turkiye

[5] Inonu Univ, Fac Arts & Sci, Dept Mol Biol & Genet, TR-44280 Malatya, Turkiye

[6] Inonu Univ, Fac Med, Dept Med Biol & Genet, TR-44280 Malatya, Turkiye

[7] Qassim Univ, Coll Sci, Dept Biol, Qasim 51452, Saudi Arabia

[8] Qassim Univ, Coll Sci, Dept Chem, Buraydah 51452, Saudi Arabia

[9] Univ Carthage, Higher Inst Environm Sci & Technol, Res Lab Environm Sci & Technol LR16ES09, Hammam Lif, Tunisia

来源：

INORGANICA CHIMICA ACTA | 2025年 / 577卷

关键词：

Catalysts; Structure analysis; Anticancer activity; Antimicrobial activity; 6-Dimethylbenzimidazole; N -Heterocyclic carbene; Silver complexes; SALTS; NHC;

D O I：

10.1016/j.ica.2024.122458

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

In this study, a new series of 1-(2-ethylhexyl)-3-(alkyl)-5,6-dimethylbenzimidazol-2-ylidene]silver(I) complexes has been synthesized and investigated their in vitro antibacterial, antifungal and anticancer properties. All molecules were characterized by 1H NMR, 13C NMR, and IR spectroscopy techniques. In vitro antimicrobial activity of the synthesized compounds investigated in this work was tested against the reference strains: Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213) and Pseudomonas aeruginosa (ATCC 27853), Candida albicans (ATCC MYA-2876) and Candida glabrata (ATCC 2001). Anticancer properties of samples were evaluated against A549, HCT116 and BEAS-2B cells lines. All silver-NHC complexes showed antibacterial activity against the tested bacterial and fungal strains.

引用

页数：8

共 50 条

[1] Novel N-Heterocyclic Carbene Silver(I) Complexes: Synthesis, Structural Characterization, Antimicrobial and Cytotoxicity Potential Studies
Slimani, Ichraf
Chakchouk-Mtibaa, Ahlem
Mellouli, Lotfi
Mansour, Lamjed
Ozdemir, Ismail
Gurbuz, Nevin
Hamdi, Naceur
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2020, 31 (10) : 2058 - 2070
[2] Novel N-heterocyclic carbene silver(I) complexes: Synthesis, structural characterization, and anticancer activity
Bolukbasi, Serap Sahin
Sahin, Neslihan
Tahir, Muhammad Nawaz F.
Arici, Cengiz
Cevik, Esranur
Gurbuz, Nevin
Ozdemir, Ismail
Cummings, Brian S.
INORGANICA CHIMICA ACTA, 2019, 486 : 711 - 718
[3] Tri N-Heterocyclic Carbene Trinuclear Silver(I) complexes: Synthesis and In Vitro cytotoxicity studies
Fatima, Tabinda
Haque, Rosenani A.
Ahmad, Ashfaq
Hassan, Loiy Elsir Ahmed
Ahamed, Mohamed B. Khadeer
Majid, A. M. S. Abdul
Razali, Mohd R.
JOURNAL OF MOLECULAR STRUCTURE, 2020, 1222
[4] Synthesis, characterization and antimicrobial activities of novel silver(I) complexes with coumarin substituted N-heterocyclic carbene ligands
Karatas, Mert Olgun
Olgundeniz, Begum
Gunal, Selami
Ozdemir, Ilknur
Alici, Bulent
Cetinkaya, Engin
BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 24 (04) : 643 - 650
[5] Synthesis and structural characterization of two novel N-heterocyclic carbene complexes of Rh(I)
Karabiyik, Hasan
Kilincarslan, Rafet
Aygun, Muhittin
Cetinkaya, Bekir
Buyukgungor, Orhan
JOURNAL OF COORDINATION CHEMISTRY, 2007, 60 (04) : 393 - 399
[6] Synthesis and structural characterization of N-heterocyclic carbene complexes of silver(I) and rhodium(I) from caffeine
Kascatan-Nebioglu, A
Panzner, MJ
Garrison, JC
Tessier, CA
Youngs, WJ
ORGANOMETALLICS, 2004, 23 (08) : 1928 - 1931
[7] Synthesis and structural characterization of N-heterocyclic carbene gold(I) complexes
de Frémont, P
Scott, NM
Stevens, ED
Nolan, SP
ORGANOMETALLICS, 2005, 24 (10) : 2411 - 2418
[8] Structural diversity of N-heterocyclic carbene complexes of silver(I)
Lee, KM
Wang, HMJ
Lin, IJB
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 2002, (14): : 2852 - 2856
[9] Synthesis, characterization and antitumor properties of novel silver(I) and gold(I) N-heterocyclic carbene complexes
Ozdemir, Ilknur
Ciftci, Osman
Evren, Enes
Gurbuz, Nevin
Kaloglu, Nazan
Turkmen, Nese Basak
Yasar, Seyma
Ustun, Elvan
Hamdi, Naceur
Mansour, Lamjed
Ozdemir, Ismail
INORGANICA CHIMICA ACTA, 2020, 506
[10] Synthesis and antimicrobial activity of novel gold(I) N-heterocyclic carbene complexes
Öznur Doğan
Nazan Kaloğlu
Serpil Demir
İlknur Özdemir
Selami Günal
İsmail Özdemir
Monatshefte für Chemie - Chemical Monthly, 2013, 144 : 313 - 319

← 1 2 3 4 5 →